Splanchnic vasoconstriction in hyperthermic man--role of falling blood pressure.
Splanchnic vasoconstriction in hyperthermic man--role of falling blood pressure.
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高温人的内脏血管收缩——血压下降的作用。
DOI：
10.1152/jappl.1971.31.6.864
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发表时间：
1971
影响因子：
3.3
通讯作者：
C. Wyss
中科院分区：
文献类型：
--
作者：
L. Rowell;J. Detry;G. R. Profant;C. Wyss
在一项研究中，六名仰卧休息的受试者穿着注水服，在两部分实验中，将身体皮肤温度控制在35 ℃ 30分钟（控制期），然后迅速升至40.5 ℃ 43至50分钟（加热期）。在第一部分的实验中，动脉平均压（MP）在三名男子增加到，或以上的控制水平，在30至35分钟的加热完全闭塞的双腿8至10分钟。内脏血流量（SBF），从1.4下降到0.9 L/min在闭塞，仅上升0.05 L/min在闭塞。内脏血管阻力（SVR）上升，整个加热和闭塞。在实验的第二部分（三名男性）SBF下降，尽管自发上升的MP和主动脉脉搏压之前，腿部闭塞。在封堵前、封堵期间和封堵后测量心输出量（CO）。阻塞使MP升高10至15 mm Hg，CO仅略微降低。结果表明，血压下降或主动脉脉压不是引起内脏血管收缩的主要原因。
Results of a study in which six supine resting subjects, wearing water-perfused suits, had body skin temperature controlled at 35 C for 30 min (control period), then rapidly increased to 40.5 C for 43 to 50 min (heating period) in a two-part experiment. In the first part of the experiment arterial mean pressure (MP) in three men was increased back to, or above control levels at the 30 to 35th min of heating by total occlusion of both legs for 8 to 10 min. Splanchnic blood flow (SBF), which had fallen from 1.4 to 0.9 L/min at occlusion, rose only 0.05 L/min during occlusion. Splanchnic vascular resistance (SVR) rose throughout heating and occlusion. In the second part of the experiment (three men) SBF fell despite a spontaneous rise in MP and aortic pulse pressure prior to leg occlusion. Cardiac output (CO) was measured just before, during and after occlusion. Occlusion raised MP 10 to 15 mm Hg and reduced CO only slightly. It is concluded that falling MP or aortic pulse pressure are not major causes of the splanchnic vasoconstriction in response to heating man.