The PITSLRE protein kinase family.
The PITSLRE protein kinase family.
复制标题
PITSLRE 蛋白激酶家族。
DOI：
10.1007/978-1-4615-1809-9_27
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Kidd,VJ
中科院分区：
文献类型：
--
作者：
Lahti,JM;Xiang,J;Kidd,VJ
p34cdc2相关蛋白激酶家族PITSLRE激酶是由人类染色体1p36.3上的三个重复串联基因的选择性剪接和启动子利用而产生的，这些基因在肿瘤发生的后期经常被删除。在快速受体和糖皮质激素介导的人T细胞凋亡过程中，PITSLRE mRNA、蛋白和酶活性被诱导。几个PITSLRE异构体是细胞凋亡过程中蛋白水解的特异性靶点，产生酶活性50 kDa的异构体。抑制该蛋白酶活性可阻断PITSLRE加工和酶激活，以及细胞凋亡。因此，PITSLRE激酶可能是凋亡信号转导途径的下游组成部分。此外，PITSLRE基因及其产物在人类神经母细胞瘤肿瘤中发生物理改变，表明它们可能是肿瘤抑制因子。
A family of p34cdc2related protein kinases, the PITSLRE kinases, is generated by alternative splicing and promoter utilization from three duplicated and tandemly linked genes on human chromosome 1p36.3, which is frequently deleted during the late stages of tumorigenesis. PITSLRE mRNA, protein, and enzyme activity are induced duringFasreceptor- and glucocorticoid-mediated apoptosis of human T cells. Several PITSLRE isoforms are specific targets of proteolysis during apoptosis, generating an enzymatically active 50 kDa isoform. Inhibition of this protease activity blocks PITSLRE processing and enzyme activation, as well as apoptosis. Thus, PITSLRE kinases may be integral downstream components of apoptotic signal transduction pathway(s). Furthermore, PITSLRE genes, and their products, are physically altered in human neuroblastoma tumors, suggesting that they may be tumor suppressors.