Synthesis of Dendrimers from Alkyne-focal Dendrons by Oxidative Homo-coupling of Terminal Acetylene
Synthesis of Dendrimers from Alkyne-focal Dendrons by Oxidative Homo-coupling of Terminal Acetylene
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DOI：
10.5012/bkcs.2011.32.11.3899
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发表时间：
2011-11-20
影响因子：
1.7
通讯作者：
Lee, Jae Wook
中科院分区：
文献类型：
--
作者：
Han, Seung Choul;Kim, Jongsik;Lee, Jae Wook
开发了通用、快速且有效的融合方法，用于合成以 1,3-二炔为核心的树枝状聚合物。合成策略采用末端炔烃的氧化自偶联。炔官能化的Frechet型树枝状大分子1-Dm的氧化自偶联反应被允许提供以1,3-二炔为核心的第一代至第四代树枝状聚合物2-Gm。炔丙基官能化的 PAMAM 树枝状大分子 3-Dm 通过末端炔的同源偶联而融合，导致对称 PAMAM 树枝状聚合物 4-Gm 的形成。通过 H-1 和 C-13 NMR 光谱、IR 光谱、质谱和 GPC 分析证实了它们的树枝状聚合物的结构。
General, fast, and efficient fusion methods for the synthesis of dendrimers with 1,3-diynes at a core were developed. The synthetic strategy was employed the oxidative homo-coupling of terminal alkyne. The oxidative homo-coupling reaction of the alkyne-functionalized Frechet-type dendrons 1-Dm was allowed to provide first through fourth generation dendrimers 2-Gm with 1,3-diynes at core. The fusion of the propargyl-functionalized PAMAM dendrons 3-Dm by homo-coupling of terminal alkyne lead to the formation of symmetric PAMAM dendrimers 4-Gm. Their structure of dendrimers was confirmed by H-1 and C-13 NMR spectroscopy, IR spectroscopy, mass spectrometry, and GPC analysis.