Mechanistic modeling of chromatin folding to understand function
Mechanistic modeling of chromatin folding to understand function
复制标题
染色质折叠的机理建模以了解其功能
DOI：
10.1038/s41592-020-0852-6
复制
发表时间：
2020-06-08
期刊：
影响因子：
48
通讯作者：
Gilbert, Nick
中科院分区：
文献类型：
--
作者：
Brackey, Chris A.;Marenduzzo, Davide;Gilbert, Nick
这一观点强调了最近开发的用于研究染色体组织的计算模型，重点是机械建模如何帮助生物学家解释基因组结构背后的生物功能。实验方法已被应用于解决理解三维染色质组织和功能的问题。随着数据集的大小和复杂性的增加，对实验结果进行机械解释成为一项挑战。聚合物模拟和机制建模已被应用于解释实验观察及其与基因组功能不同方面的联系。在这里，我们为生物学家提供了一个指南，解释了不同的模拟方法和它们被使用的背景。
This Perspective highlights recently developed computational models for studying chromosome organization, with a focus on how mechanistic modeling helps biologists to interpret the biological function behind the genome structures.Experimental approaches have been applied to address questions in understanding three-dimensional chromatin organization and function. As datasets increase in size and complexity, it becomes a challenge to reach a mechanistic interpretation of experimental results. Polymer simulations and mechanistic modeling have been applied to explain experimental observations and their links to different aspects of genome function. Here we provide a guide for biologists, explaining different simulation approaches and the contexts in which they have been used.