Developments of the incidence of osteoporosis in The Netherlands: a PHARMO study
Developments of the incidence of osteoporosis in The Netherlands: a PHARMO study
复制标题
DOI：
10.1002/pds.1245
复制
发表时间：
2007-02-01
影响因子：
2.6
通讯作者：
Herings, Ron M. C.
中科院分区：
文献类型：
--
作者：
Goettsch, Wim G.;de Jong, Romy B.;Herings, Ron M. C.
目的评估1993-2015年期间荷兰常规数据库中骨质疏松症发病率的近期和预测未来时间趋势，并将基于髋部骨折的估计值与基于药房和住院数据的替代值进行比较。方法使用荷兰医学登记处的信息估计1986-2002年期间髋部骨折的发病率，覆盖了荷兰99%以上的住院病例。此外，构建了一个替代（骨质疏松症或骨质疏松性骨折住院，糖皮质激素治疗或抗骨质疏松药物治疗），以识别PHARMO数据库中的骨质疏松患者。计算年龄和性别特异性髋部骨折和骨质疏松症的发病率，并外推至荷兰。这两项研究的结果外推到2015年使用幂function.Results髋部骨折的发病率略有下降（270每10万，1993年，260每10万，2002年）。骨质疏松症的发病率从1993年的870/10万下降到2002年的700/10万。髋部骨折和骨质疏松症的发病率在2015年建模时保持相当稳定。这两项研究显示了相同的时间trends.Conclusion的估计的基础上住院髋部骨折和我们的代理骨质疏松症显示，在20世纪90年代观察到的骨质疏松症的发病率的增加是趋于平稳。然而，由于人口老龄化，髋部骨折的绝对数量将增加。我们对骨质疏松症的定义导致了对骨质疏松症发病率的更高估计，并可用于未来的研究，以跟踪骨质疏松症患病率和发病率的发展。版权所有（c）2006约翰威利父子有限公司。
Purpose To assess recent and to predict future time trends in the incidence of osteoporosis using routine databases in The Netherlands in the period 1993-2015 and to compare estimations based on hip fractures versus a proxy based on pharmacy and hospitalisation data.Methods The incidence of hip fractures was estimated over the period 1986-2002 using information from the Dutch Medical Registry, covering more than 99% of all Dutch hospitalisations. Additionally, a proxy (hospitalisation for osteoporosis or osteoporotic fractures, treatment with glucocorticosteroids or treatment with anti-osteoporosis drugs) was constructed in order to identify osteoporotic patients in the PHARMO database. Age and gender specific incidences of hip fractures and osteoporosis were calculated and extrapolated to The Netherlands. Results of both studies were extrapolated till 2015 using a power function.Results The incidence of hip fractures decreased slightly (270 per 100000 in 1993, 260 per 100000 in 2002). The incidence of osteoporosis using the constructed proxy decreased from 870 per 100 000 in 1993 to 700 per 100 000 in 2002. The incidence of hip fractures and osteoporosis remained fairly constant when modelled till 2015. Both studies showed the same time trends.Conclusion Both the estimations based on the hospitalisations for hip fracture and on our proxy for osteoporosis showed that the increase in the incidence of osteoporosis as observed in the 1990s is levelling off. Due to ageing of the population the absolute number of hip fractures will however increase. Our definition of osteoporosis resulted in a higher estimation of the incidence of osteoporosis and may be used in future studies to follow developments in osteoporosis prevalence and incidence. Copyright (c) 2006 John Wiley & Sons, Ltd.