Ultrasound-mediated drug delivery to the brain: principles, progress and prospects.
Ultrasound-mediated drug delivery to the brain: principles, progress and prospects.
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DOI：
10.1016/j.ddtec.2016.07.007
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发表时间：
2016-06
期刊：
影响因子：
--
通讯作者：
Lammers, Twan
中科院分区：
文献类型：
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作者：
Dasgupta, Anshuman;Liu, Mengjiao;Ojha, Tarun;Storm, Gert;Kiessling, Fabian;Lammers, Twan
血脑屏障（BBB）限制药物进入中枢神经系统。当与微泡结合时，超声波可以短暂地渗透到大脑的血管中。这种方法被称为超声穿孔或超声透入化，在穿梭大的治疗分子（如抗体、生长因子和纳米药物配方）穿过血脑屏障方面具有重要的前景。我们在此描述了利用超声和微泡渗透血脑屏障的基本原理，并总结了几项（预）临床研究，这些研究显示了血脑屏障开放在改善癌症和神经退行性疾病治疗方面的潜力。
The blood-brain barrier (BBB) limits drug delivery to the central nervous system. When combined with microbubbles, ultrasound can transiently permeate blood vessels in the brain. This approach, which can be referred to as sonoporation or sonopermeabilization, holds significant promise for shuttling large therapeutic molecules, such as antibodies, growth factors and nanomedicine formulations, across the BBB. We here describe the basic principles of BBB permeation using ultrasound and microbubbles, and we summarize several (pre-) clinical studies showing the potential of BBB opening for improving the treatment of cancer and neurodegenerative disorders.