Cerebral Blood Flow Autoregulation and Dysautoregulation.
Cerebral Blood Flow Autoregulation and Dysautoregulation.
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DOI：
10.1016/j.anclin.2016.04.002
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发表时间：
2016-09-01
影响因子：
--
通讯作者：
Armstead, William M
中科院分区：
文献类型：
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作者：
Armstead, William M
本文提供了一个审查的大脑自动调节，特别是因为它涉及到临床科学家在神经科学经验丰富的麻醉和重症监护。所涵盖的主题是生物学机制;用于评估自动调节的方法;麻醉剂的影响;在健康和疾病中控制脑血流动力学的作用;以及新兴领域，如年龄和性别对自动调节障碍的作用。重点放在双向转化研究，其中临床通知基础科学研究的研究设计，这反过来又通知临床，从而开发出治疗中枢神经系统疾病的改进疗法。
This article provides a review of cerebral autoregulation, particularly as it relates to the clinician scientist experienced in neuroscience in anesthesia and critical care. Topics covered are biological mechanisms; methods used for assessment of autoregulation; effects of anesthetics; role in control of cerebral hemodynamics in health and disease; and emerging areas, such as role of age and sex in contribution to dysautoregulation. Emphasis is placed on bidirectional translational research wherein the clinical informs the study design of basic science studies, which, in turn, informs the clinical to result in development of improved therapies for treatment of central nervous system conditions.