Social network and coronary artery calcification in asymptomatic individuals
Social network and coronary artery calcification in asymptomatic individuals
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DOI：
10.1097/01.psy.0000161201.45643.8d
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发表时间：
2005-05-01
影响因子：
3.3
通讯作者：
Rozanski, A
中科院分区：
文献类型：
--
作者：
Kop, WJ;Berman, DS;Rozanski, A
背景：心理社会因素与冠状动脉疾病的发生有关。然而，将心理社会因素作为冠状动脉钙化（CAC）风险指标的研究尚未得出结论。方法：783 名参与者（平均年龄 57.4 +/- 9.3 岁，47% 为女性）使用电子束断层扫描进行了 CAC 成像。心理社会测量包括社交网络（家庭人数、婚姻状况）、社会经济状况（教育、收入和工作状况）、抑郁病史以及使用流行病学研究中心抑郁症（CES-D）量表评估的当前抑郁症状。还对血脂、血糖、血压和健康行为（吸烟状况、运动和饮食）进行了评估。结果：351 名 (44.8%) 参与者出现钙化（CAC 评分范围 0-3022；平均值 111.5 +/- 307.2）。即使在调整年龄、性别、收缩压、血糖和低密度脂蛋白后，社会隔离指标（单身或丧偶）与 CAC 存在风险升高独立相关（调整后的比值比分别为 1.80，95% 置信区间 [CI] = 1.05-3.10 和 2.48，95% CI = 1.02-6.03）。相比之下，健康行为、社会经济地位和抑郁症状与 CAC 无关。结论：单身或丧偶等社交网络指数与 CAC 相关，与年龄和冠状动脉危险因素无关。由于冠状动脉钙化已被确定为早期动脉粥样硬化的潜在标志，因此这些发现可能部分解释了有限的社交网络对未来不良心血管健康结果的预测价值。
Background: Psychosocial factors are associated with the development of coronary artery disease. However, studies examining psychosocial factors as risk indicators for coronary artery calcification (CAC) have been inconclusive. Methods: Seven hundred eighty-three participants (mean age 57.4 +/- 9.3 years, 47% female) underwent CAC imaging using electron beam tomography. Psychosocial measures included social network (number of people in the household, marital status), socioeconomic status (education, income, and work status), history of depression, and current depressive symptoms as assessed with the Center for Epidemiologic Studies Depression (CES-D) scale. Assessments were also made for lipid profile, blood glucose, blood pressure, and health behaviors (smoking status, exercise, and diet). Results: Calcification was present in 351 (44.8%) participants (CAC score range 0-3022; mean 111.5 +/- 307.2). Indicators of social isolation (being single or widowed) were independently associated with elevated risk for the presence of CAC, even after adjustment for age, sex, systolic blood pressure, blood glucose, and low-density lipoprotein (adjusted odds ratios 1.80, 95% confidence interval [CI] = 1.05-3.10, and 2.48, 95% CI = 1.02-6.03, respectively). By contrast, health behaviors, socioeconomic status, and depressive symptoms were not related to CAC. Conclusions: Social network indices such as being single or widowed are associated with CAC, independent of age and coronary risk factors. Because coronary calcification has been identified as a potential marker of early atherosclerosis, these findings may partially explain the predictive value of limited social networks for future adverse cardiovascular health outcomes.