Surface area of chorionic villi of placentas: An index of intrauterine growth restriction of fetuses
Surface area of chorionic villi of placentas: An index of intrauterine growth restriction of fetuses
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DOI：
10.1111/j.1447-0756.2008.00719.x
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发表时间：
2008-08-01
影响因子：
1.6
通讯作者：
Chhabra, Shakuntala
中科院分区：
文献类型：
--
作者：
Biswas, Sharmistha;Ghosh, Samit K.;Chhabra, Shakuntala
目的：对特发性宫内生长受限（IUGR）胎儿以及正常体重（对照）胎儿的胎盘进行组织形态计量学研究，以使用体视技术确定绒毛膜绒毛（主要是末端和少数中间绒毛）的表面积。比较结果以确定绒毛膜绒毛表面积值的差异，并建立胎盘组织形态变化与 IUGR 之间的关系。 方法：收集五十 (50) 例足月、无并发症的分娩者的胎盘；其中二十八 (28) 名与 IUGR 婴儿相关，二十二 (22) 名来自正常体重婴儿。测量胎盘重量和体积。将胎盘组织碎片用福尔马林固定、处理并包埋在石蜡中。切割七微米切片并用HE染色。进行组织形态计量学和体视学研究。结果：IUGR 胎盘重量和体积低于对照组。 IUGR 胎盘绒毛表面积的平均值为 8.19 m(2) (SD +/- 2.88)。对于对照胎盘，平均值为 10.02 m(2) (SD +/- 1.83)。 IUGR组绒毛表面积平均值显着低于对照组。结论：这些发现表明滋养层与母体组织之间的正常相互作用存在缺陷，导致绒毛表面积减少。由于绒毛表面积是母体和胎儿循环之间的界面，其减少可能是特发性宫内生长受限的原因。
Aim: Histomorphometric studies of placentas from idiopathic intrauterine growth restricted (IUGR) fetuses as well as normal-weight (control) fetuses were performed to determine surface area of chorionic villi (mostly terminal and few intermediate) using stereological technique. The results were compared to determine the difference in the values of surface area of chorionic villi, and to establish any relationship between placental histomorphometric changes and IUGR.Methods: Placentas from fifty (50) full-term, uncomplicated deliveries were collected; twenty eight (28) of them were associated with IUGR babies and twenty two (22) were from normal-weight babies. Placental weights and volumes were measured. Pieces of placental tissues were formalin-fixed, processed and embedded in paraffin. Seven-micron sections were cut and stained with HE stain. Histomorphometric and stereological studies were performed.Results: IUGR placental weights and volumes were lower than those of controls. Surface areas of villi of IUGR placentas had a mean of 8.19 m(2) (SD +/- 2.88). For control placentas, the mean was 10.02 m(2) (SD +/- 1.83). The mean value of the surface area of villi of the IUGR group was significantly lower than that of the control group.Conclusion: These findings pointed to a defect in the normal interaction between trophoblast and maternal tissue, leading to a reduced surface area of villi. Because the surface area of the villi presents the interface between maternal and fetal circulation, its reduction might be the cause of idiopathic intrauterine growth restriction.