Cerenkov luminescence imaging: physics principles and potential applications in biomedical sciences.
Cerenkov luminescence imaging: physics principles and potential applications in biomedical sciences.
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DOI：
10.1186/s40658-017-0181-8
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发表时间：
2017-12
期刊：
影响因子：
4
通讯作者：
Belcari N
中科院分区：
文献类型：
--
作者：
Ciarrocchi E;Belcari N
切伦科夫发光成像（CLI）是一种利用光学方法研究带电粒子在生物组织中产生的切伦科夫发光的新型成像方式。本文首先介绍了切伦科夫发光的产生和组织中的传输的物理过程。用于CLI和他们最相关的规格，以优化采集的切伦科夫信号的检测器，然后CLI与其他光学成像模式共享相同的数据采集和处理方法进行了比较。最后，有关CLI的科学工作和CLI已提出的应用程序进行了审查。本文最后对这种新型成像方式的进一步前景进行了一些考虑。
Cerenkov luminescence imaging (CLI) is a novel imaging modality to study charged particles with optical methods by detecting the Cerenkov luminescence produced in tissue. This paper first describes the physical processes that govern the production and transport in tissue of Cerenkov luminescence. The detectors used for CLI and their most relevant specifications to optimize the acquisition of the Cerenkov signal are then presented, and CLI is compared with the other optical imaging modalities sharing the same data acquisition and processing methods. Finally, the scientific work related to CLI and the applications for which CLI has been proposed are reviewed. The paper ends with some considerations about further perspectives for this novel imaging modality.