INHIBITION OF THE IRON-CATALYZED FORMATION OF HYDROXYL RADICALS FROM SUPEROXIDE AND OF LIPID PEROXIDATION BY DESFERRIOXAMINE
INHIBITION OF THE IRON-CATALYZED FORMATION OF HYDROXYL RADICALS FROM SUPEROXIDE AND OF LIPID PEROXIDATION BY DESFERRIOXAMINE
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DOI：
10.1042/bj1840469
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发表时间：
1979-01-01
影响因子：
4.1
通讯作者：
HALLIWELL, B
中科院分区：
文献类型：
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作者：
GUTTERIDGE, JMC;RICHMOND, R;HALLIWELL, B
在体外由抗坏血酸或由dialuric酸（羟基巴比妥酸）诱导的[牛脑]膜磷脂的过氧化在没有痕量金属离子的情况下不会发生。通过向磷脂中加入铁盐诱导的过氧化作用可以被螯合剂EDTA、二亚乙基三胺五乙酸和浴-菲咯啉磺酸盐促进或抑制，这取决于[螯合剂]/[铁盐]的比例。铁螯合剂去铁胺在所有测试浓度下均抑制过氧化反应，并且还抑制铁催化的羟基自由基（OH）的形成。超氧化物（O2-）。由于去铁胺已被批准用于临床，它可能被证明是治疗炎症、自氧化分子中毒和辐射损伤的有价值的工具。
The peroxidation of [bovine brain] membrane phospholipids induced in vitro by ascorbic acid or by dialuric acid (hydroxybarbituric acid) does not occur in the absence of traces of metal ions. Peroxidation induced by adding iron salts to phospholipids can either be promoted or inhibited by the chelators EDTA, diethylenetriaminepenta-acetic acid and batho-phenanthrolinesulfonate, depending on the ratio [chelator]/[iron salt]. The iron chelator deferrioxamine inhibits peroxidation at all concentrations tested, and it also inhibits the iron-catalyzed formation of hydroxyl radicals (OH.) from superoxide (O2-.). Since deferrioxamine is approved for clinical use, it might prove a valuable tool in the treatment of inflammation, poisoning by autoxidizable molecules and radiation damage.