It is all about the process(ing): P-body granules and the regulation of signal transduction.
It is all about the process(ing): P-body granules and the regulation of signal transduction.
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这一切都与过程有关：P-体颗粒和信号转导的调节。
DOI：
10.1007/s00294-019-01016-3
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发表时间：
2020
期刊：
影响因子：
2.5
通讯作者：
Herman,PK
中科院分区：
文献类型：
--
作者：
Zhang,B;Herman,PK
真核细胞通过膜结合和无膜细胞器的存在被细分为不同的功能域。后者包括细胞质颗粒，如加工体（P体），其在应激反应中被诱导，并含有特定的mRNA和蛋白质组。虽然P体在进化上是保守的，但我们还不了解它们在细胞中的全部生物学功能。早期的研究表明，这些结构可能是mRNA衰变的位点，因为第一个被鉴定的蛋白质成分是参与mRNA加工的酶。然而，最近的研究表明，这不太可能是这些颗粒的主要功能，甚至表明P体是长期mRNA储存的场所。有趣的是，已经发现P体和其他核糖核蛋白颗粒也含有各种信号分子，包括对细胞生长和存活的正常控制至关重要的蛋白激酶和磷酸酶。因此，P-体可能在特定类型的应激过程中调节细胞信号传导中发挥作用。这篇评论讨论了这样一个建议的一般意义和一个特定的例子，说明了颗粒招聘的蛋白激酶可以影响整体细胞生理。
The eukaryotic cell is subdivided into distinct functional domains by the presence of both membrane-bound and membraneless organelles. The latter include cytoplasmic granules, like the Processing-body (P-body), that are induced in response to stress and contain specific sets of mRNAs and proteins. Although P-bodies have been evolutionarily conserved, we do not yet understand the full extent of their biological functions in the cell. Early studies suggested that these structures might be sites of mRNA decay as the first protein constituents identified were enzymes involved in mRNA processing. However, more recent work indicates that this is not likely to be the primary function of these granules and has even suggested that P-bodies are sites of long-term mRNA storage. Interestingly, P-bodies and other ribonucleoprotein granules have been found to also contain a variety of signaling molecules, including protein kinases and phosphatases key to the normal control of cell growth and survival. Therefore, P-bodies could have a role in the modulation of cell signaling during particular types of stress. This review discusses both the general implications of such a proposal and one particular example that illustrates how the granule recruitment of a protein kinase can impact overall cell physiology.