Long Noncoding RNA Discovery in Cardiovascular Disease: Decoding Form to Function.
Long Noncoding RNA Discovery in Cardiovascular Disease: Decoding Form to Function.
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DOI：
10.1161/circresaha.117.311802
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发表时间：
2018-01-05
影响因子：
20.1
通讯作者：
Tontonoz P
中科院分区：
文献类型：
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作者：
Sallam T;Sandhu J;Tontonoz P
尽管在过去三十年中取得了显着改善，心血管疾病仍然是全球主要的健康流行病。最近发现了一组令人着迷的介质，称为长非编码 RNA (lncRNA)，为探索降低心血管风险提供了丰富的新生物学知识。 lncRNA 以高度特定的方式表达，多种证据表明它们与不同的生物过程有关。事实上，lncRNA 的异常与人类疾病直接相关，包括心血管生物学和疾病。心血管研究界特别感兴趣的是，lncRNA 调节回路的失调与心脏病病理性肥大、血管疾病、细胞命运编程和发育、动脉粥样硬化、血脂异常和代谢综合征有关。尽管检测非编码 RNA 的技术正在迅速发展，但研究 lncRNA 的一个主要挑战仍然是克服多种技术限制。在这篇综述中，我们提供了在与心血管疾病相关的生物系统中发现和研究 lncRNA 的路线图，并重点介绍了破译其作用模式的方法。
Despite significant improvements during the past 3 decades, cardiovascular disease remains a leading worldwide health epidemic. The recent identification of a fascinating group of mediators known as long noncoding RNAs (lncRNAs) has provided a wealth of new biology to explore for cardiovascular risk mitigation. lncRNAs are expressed in a highly context-specific fashion, and multiple lines of evidence implicated them in diverse biological processes. Indeed, abnormalities of lncRNAs have been directly linked with human ailments, including cardiovascular biology and disease. Of particular interest to the cardiovascular research community, dysregulation in lncRNA regulatory circuits have been associated with cardiac pathological hypertrophy, vascular disease, cell fate programming and development, atherosclerosis, dyslipidemia, and metabolic syndrome. Although techniques in interrogating noncoding RNAs are rapidly evolving, a major challenge in studying lncRNAs remains navigating through multiple technical constraints. In this review, we provide a road map for lncRNA discovery and interrogation in biological systems relevant to cardiovascular disease and highlight approaches to decipher their modes of action.