Increasing prevalence of type II diabetes in American Indian children
Increasing prevalence of type II diabetes in American Indian children
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DOI：
10.1007/s001250051006
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发表时间：
1998-08-01
期刊：
影响因子：
8.2
通讯作者：
Pettitt, DJ
中科院分区：
文献类型：
--
作者：
Dabelea, D;Hanson, RL;Pettitt, DJ
直到最近，II型糖尿病被认为是罕见的儿童。然而，在成人II型糖尿病发病率较高的人群中，这种疾病在儿童中正在增加。1967年至1996年，在3个10年的时间段内，对5-9岁、10-14岁和15-19岁年龄组的5274名皮马印第安儿童进行了II型糖尿病患病率测定。糖尿病是根据口服葡萄糖耐量试验，使用世界卫生组织标准诊断的。随着时间的推移，10岁及以上儿童的糖尿病患病率增加：在10-14岁年龄组的男孩中，从1967 - 1976年的0%增加到1987-1996年的1.4%，15-19岁年龄组和10-14岁年龄组女孩的死亡率从1967-1976年的0.72%上升到1987-1996年的2.88%，15-19岁年龄组从2.73%上升到5.31%。沿着II型糖尿病患病率的增加（p < 0.0001），体重（以相对体重的百分比计算，p < 0.0001）和子宫内糖尿病暴露频率也增加（p < 0.0001）。体重增加和子宫内糖尿病暴露频率增加是过去30年皮马印第安儿童糖尿病患病率增加的主要原因。II型糖尿病现在是10岁或10岁以上的美国印第安儿童的常见疾病，随着时间的推移，沿着体重的增加而急剧增加。与子宫内糖尿病发病率增加有关的恶性循环似乎是这一流行病的一个重要特征。
Until recently, Type II diabetes was considered rare in children. The disease is, however, increasing among children in populations with high rates of Type II diabetes in adults. The prevalence of Type II diabetes was determined in 5274 Pima Indian children between 1967 and 1996 in three 10-year time periods, for age groups 5-9, 10-14 and 15-19 years. Diabetes was diagnosed using World Health Organisation criteria, based on an oral glucose tolerance test. The prevalence of diabetes increased over time in children aged 10 years and over: in boys from 0% in 1967-1976 to 1.4% in 1987-1996 in the 10-14 year old age group, and from 2.43% to 3.78% for age group 15-19 and in girls from 0.72% in 1967-1976 to 2.88% in 1987-1996 in the 10-14 year old age group, and from 2.73% to 5.31% for age group 15-19 years. Along with the increase in the prevalence of Type II diabetes (p < 0.0001), there was an increase in weight (calculated as percentage of relative weight, p < 0.0001), and in frequency of exposure to diabetes in utero (p < 0.0001). The increasing weight and increasing frequency of exposure to diabetes in utero accounted for most of the increase in diabetes prevalence in Pima Indian children over the past 30 years. Type II diabetes is now a common disease in American Indian children aged 10 or more years and has increased dramatically over time, along with increasing weight. A vicious cycle related to an increase in the frequency of exposure to diabetes in utero appears to be an important feature of this epidemic.