EFFECT OF TRICYCLIC ANTIDEPRESSANT DRUGS ON HEART
EFFECT OF TRICYCLIC ANTIDEPRESSANT DRUGS ON HEART
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DOI：
10.1007/bf00570267
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发表时间：
1976-01-01
影响因子：
6.1
通讯作者：
SCOGGINS, BA
中科院分区：
文献类型：
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作者：
DUMOVIC, P;BURROWS, GD;SCOGGINS, BA
观察每分钟1.0 mg/kg输注抗替林、多虑平、丙咪嗪、去甲替林对麻醉豚鼠心率和心电图的影响，直至死亡。此外，对豚鼠心房进行了一项体外研究，研究这些药物以及浓度为 10-5 M 的去甲基丙咪嗪和普罗替林的变时性和正性肌力作用。还评估了碳酸氢钠（3 meq/kg 静脉注射）和普萘洛尔（0.01-0.2 mg/kg 静脉注射）对阿米替林和多塞平引起的心电图变化的影响。观察到体内和体外模型对心脏的影响存在差异。注射多虑平的豚鼠比注射阿米替林、丙咪嗪或去甲替林的豚鼠存活时间明显更长。在 QRS 波群增宽、PR 和 QT 间期增加方面，三环类药物之间没有发现统计学上的显着差异。在自发性心房准备中，多塞平是最有效的心脏抑制剂。碳酸氢钠对三环类药物引起的心律失常没有作用，而普萘洛尔除了引起心动过缓外，对心电图没有有益作用。豚鼠为研究三环类抗抑郁药的致心律失常作用提供了一个良好的模型。
The effects on the heart rate and ECG of anesthetised guinea pigs of antitriptyline, doxepin, imipramine and nortriptyline infused at 1.0 mg/kg per min until death were observed. In addition an in vitro study on guinea pig atria was performed on the chronotropic and inotropic effects of these drugs and of desmethylimipramine and protriptyline at a concentration of 10-5 M. The effect of sodium bicarbonate (3 meq/kg i.v.) and propranolol (0.01-0.2 mg/kg i.v.) on amitriptyline and doxepin induced ECG changes was also assessed. A difference in the cardiac effects of the in vivo and in vitro model was observed. Guinea pigs infused with doxepin survived significantly longer than those infused with amitriptyline, imipramine or nortriptyline. No statistically significant difference was found between the tricyclic drugs with respect to onset of widening of the QRS complex, increased PR and QT intervals. In the spontaneously beating atrial preparation doxepin was the most potent cardio-depressant. Sodium bicarbonate had no effect on arrhythmias induced by tricyclics, while propranolol, apart from the bradycardia induced, was without beneficial effect on the ECG. The guinea pig provides a good model for studying the arrhythmogenic actions of tricyclic antidepressants.