Longitudinal Changes in Body Composition by Dual-energy Radiograph Absorptiometry Among Perinatally HIV-infected and HIV-uninfected Youth: Increased Risk of Adiposity Among HIV-infected Female Youth.
Longitudinal Changes in Body Composition by Dual-energy Radiograph Absorptiometry Among Perinatally HIV-infected and HIV-uninfected Youth: Increased Risk of Adiposity Among HIV-infected Female Youth.
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DOI：
10.1097/inf.0000000000001963
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发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Miller TL
中科院分区：
文献类型：
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作者：
Sharma TS;Somarriba G;Arheart KL;Neri D;Mathew MS;Graham PL;Scott GB;Miller TL
抗逆转录病毒联合治疗（cART）使围产期艾滋病毒感染（PHIV+）的青少年能够活到成年，但许多年轻人可能经历代谢和身体成分的变化，易患更大的心血管疾病（CVD）风险。这项纵向研究评估了在7年的时间里，与HIV -对照组相比，PHIV+青年队列中双x线吸收仪（DXA）测量的身体成分的变化。PHIV阳性青年和HIV阴性青年前瞻性地纳入了一项单点研究，以评估营养和心血管疾病的风险。纵向获得人体测量和DXA扫描，以评估体脂百分比和区域脂肪分布。使用一般线性模型，我们分析了PHIV阳性青年和对照组之间随时间变化的身体组成和人体测量的性别差异。纳入研究入组以来至少进行过一次DXA的235名参与者（156名HIV阳性，79名HIV阴性对照）进行分析。在研究期间，PHIV+组获得471例dxa， HIV -对照组获得95例。随着时间的推移，与HIV阴性女性相比，HIV阳性女性的体重和BMI增加更大，与HIV阴性女性和HIV阳性男性相比，总体脂率（估计为每年1.212 [95%CI=0.837, 1.587] %, p<0.001）和躯干脂肪率（1.3818 [95%CI=0.922, 1.84], p<0.001）显著增加。随着时间的推移，PHIV阳性女性在脂肪再分配和体脂百分比方面表现出不利的变化，超过了PHIV阳性男性或HIV阴性女性的模式。提供者应提高对PHIV阳性女性身体成分变化的认识，这可能最终导致心血管疾病风险增加。
Combination antiretroviral therapy (cART) has allowed youth with perinatal HIV infection (PHIV+) to live into adulthood, but many youth may experience metabolic and body composition changes that predispose to greater cardiovascular disease (CVD) risk. This longitudinal study evaluated changes in body composition measured by dual x-ray absorptiometry (DXA) in a cohort of PHIV+ youth compared to HIV− controls over a 7-year period. PHIV+ youth and HIV− controls were prospectively enrolled in a single-site study to assess nutrition and CVD risk. Anthropometrics and DXA scans were longitudinally obtained to assess percent body fat and regional fat distribution. Using general linear models, we analyzed differences in body composition and anthropometric measures by sex between PHIV+ youth and controls over time. 235 participants (156 PHIV+, 79 HIV− controls) with at least one DXA performed since study enrollment were included for analysis. During the study period, 471 DXAs were obtained in the PHIV+ group and 95 in HIV− controls. PHIV+ females demonstrated greater increase in weight and BMI over time compared to HIV− females, and significant increases in total percent body fat (estimate=1.212 [95%CI=0.837, 1.587] percent per year, p<0.001) and percent trunk fat (1.3818 [95%CI=0.922, 1.84], p<0.001) compared to HIV− females and PHIV+ males. PHIV+ females demonstrate an unfavorable change in fat redistribution and percent body fat over time that exceeds the pattern seen in PHIV+ males or HIV− females. Providers should have heightened awareness of body composition changes of PHIV+ females that may eventually lead to increased CVD risk.