Interrelationships Between Serologic Markers of Immune Activation and T Lymphocyte Subsets in HIV Infection
Interrelationships Between Serologic Markers of Immune Activation and T Lymphocyte Subsets in HIV Infection
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HIV 感染中免疫激活血清学标志物与 T 淋巴细胞亚群之间的相互关系
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
A. Williams
中科院分区：
文献类型：
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作者：
H. Prince;S. Kleinman;C. Czaplicki;Judith John;A. Williams
在 HIV 血清阳性前献血者 (N = 64) 和血清阴性对照 (N = 61) 中测量了四种血清学激活标记物和 T 细胞亚群之间的关系。在可溶性 IL-2 受体 (sIL-2R)、β-微球蛋白 (β2M)、新蝶呤 (NEOP) 和可溶性 CD8 (sCD8) 的两两比较中，HIV 组观察到显着相关性。HIV 组中的 CD4 细胞水平（数量/（μl））与所有四种血清学标志物显示显着负相关；相比之下，CD8 细胞水平与测量的任何血清学激活标志物均无显着相关性。然而，观察到，在各种细胞表面活化标记物和血清学活化标记物中，表达CD45RA的CD8细胞比例与NEOP和B2M水平呈显着负相关，而表达HLA-DR的CD8细胞比例与B2M和sIL-2R水平呈显着正相关。此外，表达CD38的CD8细胞比例与所有四种血清学活化标记物呈显着正相关。和 sCD8 在 HIV 感染中表现出相似的数量变化和与 CD4 细胞破坏的相关关系；然而，它们与活化的 CD8 细胞亚群的比例变化的关系不同。
Relationships among four serologic activation markers and T cell subsets were measured in HIV-seropositive former blood donors (N = 64) and seronegative controls (N = 61). Significant correlations were observed for the HIV group in pairwise comparisons of soluble IL-2 receptor (sIL-2R), (β-microglobulin (β2M), neopterin (NEOP), and soluble CD8 (sCD8). CD4 cell levels (number/(μl) in the HIV group showed significant negative correlation with all four serologic markers; CD8 cell levels, in contrast, showed no significant correlation with any serologic activation marker measured. Significant correlations were observed, however, among various cell surface activation markers and serologic activation markers. Specifically, the proportion of CD8 cells expressing CD45RA showed significant negative correlations with NEOP and B2M levels, whereas the proportion of CD8 cells expressing HLA-DR showed significant positive correlations with B2M and sIL-2R levels. Further, the proportion of CD8 cells expressing CD38 showed significant positive correlations with all four serologic activation markers. These findings indicate that sIL-2R, B2M, NEOP, and sCD8 show similar quantitative changes and correlational relationships to CD4 cell destruction in HIV infection; they differ, however, in their relationships to proportional changes in activated CD8 cell subsets.