Changing nomenclature for PBC: From 'cirrhosis' to 'cholangitis'
Changing nomenclature for PBC: From 'cirrhosis' to 'cholangitis'
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DOI：
10.1016/j.clinre.2015.08.001
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发表时间：
2015-10-01
影响因子：
2.7
通讯作者：
Poupon, Raoul
中科院分区：
文献类型：
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作者：
Beuers, Ulrich;Gershwin, M. Eric;Poupon, Raoul
会前该领域专家之间的电子邮件讨论，以及在米兰举行的EASL单一专题会议期间的激烈讨论以及会后的持续电子邮件交流，导致了世界上绝大多数专家的普遍看法：(1)应更改“原发性胆汁性肝硬化”的名称[正如希拉·夏洛克夫人在1959年所提倡的那样]。此外，下列建议得到了讨论者的广泛支持：（二）尽可能保留简称“PBC”；(3)只要原发性胆汁性肝硬化的确切发病机制尚不明确，因此没有“理想的”替代方法，就应该使用简单的短期治疗（不完美是可以接受的）。在欧洲和美国患者的支持不断增加的同时，在该领域的国际专家中进行了几项调查。在EASL选定的委员会成员和EASL胆汁淤积性肝病管理指南的高级审稿人（n= 15）中，100%的人同意更改原发性胆汁性肝硬化的名称，100%的人投票赞成保留缩写“PBC”。60%首选“原发性胆道胆管炎”，20%首选“原发性胆道胆管病”，20%首选其他各种名称。来自美国肝病研究协会（AASLD）、亚太肝脏研究协会（APASL）和EASL [EASL委员会外]的国际专家（n= 16）中，88%的人同意将原发性胆汁性肝硬化更名，88%的人投票赞成保留缩写“PBC”。56%选择“原发性胆道胆管炎”，13%选择“原发性胆道胆管病”，38%选择其他各种名称。在日本专家（n= 18）中，100%的人同意更改原发性胆汁性肝硬化的名称，78%的人投票赞成保留缩写PBC。61%的人选择“原发性胆道胆管炎”，28%的人选择“原发性胆道胆管病”，11%的人选择其他名称。因此，考虑到命名上的不完美是可以接受的，“原发性胆管炎”作为PBC的新名称得到了世界范围内专家的最广泛支持。
E-mail discussions among experts in the field before the meeting, as well as intense discussions during the EASL Monothematic Conference in Milan with continual e-mail exchanges after the meeting has led to the widespread view among the vast majority of worldwide experts that;(1) the name ‘primary biliary cirrhosis’ should be changed [as advocated by Dame Sheila Sherlock in 1959]. In addition, the following proposals found broad support among the discussants;(2) the acronym ‘PBC’should be kept if possible;(3) a simple and short term should be used (imperfection acceptable) as long as the exact pathogenesis of primary biliary cirrhosis remained undefined and, therefore, an ‘ideal’replacement is not available.In parallel with the growing patient support from Europe and the US, several surveys were performed among international experts in the field. Among EASL-selected committee members and senior reviewers of the EASL Guidelines for management of cholestatic liver diseases (n= 15), 100% agreed to a name change for primary biliary cirrhosis and 100% voted to keep the abbreviation ‘PBC’. 60% preferred ‘primary biliary cholangitis’, 20%‘primary biliary cholangiopathy’, and 20% various other names. Among international experts from the American Association for the Study of Liver Disease (AASLD), Asian Pacific Association for the Study of the Liver (APASL) and EASL [outside the EASL committees](n= 16), 88% agreed to a name change for primary biliary cirrhosis and 88% voted to keep the abbreviation ‘PBC’. 56% preferred ‘primary biliary cholangitis’, 13%‘primary biliary cholangiopathy’, and 38% various other names. Among Japanese experts (n= 18), 100% agreed to a name change for primary biliary cirrhosis and 78% voted to keep the abbreviation PBC. 61% preferred ‘primary biliary cholangitis’, 28%‘primary biliary cholangiopathy’, and 11% various other names. Thus, considering that imperfection was acceptable in name finding,‘primary biliary cholangitis’ found the broadest support as the new name for PBC among experts worldwide.