Genomic structural variation in affective, anxiety, and stress-related disorders.
Genomic structural variation in affective, anxiety, and stress-related disorders.
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情感、焦虑和压力相关疾病的基因组结构变异。
DOI：
10.1007/s00702-014-1309-9
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Deckert J
中科院分区：
文献类型：
--
作者：
Ono S;Domschke K;Deckert J
焦虑和压力相关的障碍是常见的和使人衰弱的精神疾病。遗传因素以及环境因素和生活事件有助于其发病机制，并部分介导治疗反应。然而，这些疾病在临床上是异质性的，遗传复杂的，确切的遗传原因仍不清楚。最近，一些证据表明，结构变异包括拷贝数变异和小的缺失/重复与精神障碍有关。在这里，目前的知识状态的作用，基因组结构变异的情感，焦虑和压力相关的疾病进行审查，其次是一个关键的讨论，目前的方法来检测结构变化，未来的发展方向和临床意义，包括在个性化医疗的潜在作用。
Anxiety and stress-related disorders are common and debilitating mental diseases. Genetic factors as well as environmental factors and life events contribute to their pathogenesis and partly mediate treatment response. However, these disorders are clinically heterogeneous, genetically complex, and the exact genetic causes are still unclear. Recently, some evidence has emerged for structural variation including copy number variants and small deletions/duplications to be associated with mental disorders. Here, the current state of knowledge on the role of genomic structural variation in affective, anxiety and stress-related disorders is reviewed, followed by a critical discussion of present methods to detect structural changes, future directions, and clinical implications including a potential role in personalized medicine.