Lithium prophylaxis of depression in unipolar, bipolar II, and cyclothymic patients.
Lithium prophylaxis of depression in unipolar, bipolar II, and cyclothymic patients.
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单相、双相 II 型和循环性患者的抑郁症的锂预防。
DOI：
10.1097/00004714-198212000-00022
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
A. Lautin
中科院分区：
文献类型：
--
作者：
E. Peselow;D. Dunner;R. Fieve;A. Lautin
作者通过纵向生命表分析评估了锂对单极（N = 43）、双相（N = 102）和周期性胸廓（N = 69）患者抑郁的预防作用，并计算了持续无抑郁发作的概率。服用锂治疗2年后，双相II型患者无抑郁发作的概率为42% - 55%，单极患者为31% - 42%，循环胸腺病患者为26% - 36%。在2年的时间里，遭受一次严重到需要药物干预或住院治疗的抑郁发作的平均概率在双相II型患者中为51%，在单相患者中为64%，在循环胸腺病患者中为69%。
The authors assessed lithium's prophylactic effect against depression in unipolar (N = 43), bipolar II (N = 102), and cyclothymic (N = 69) patients using a longitudinal life-table analysis and calculated the probability of remaining free of a depressive episode. The probability of remaining free of one depressive episode after 2 years of taking lithium ranged from 42% to 55% for the bipolar II patients, 31% to 42% for the unipolar patients, and 26% to 36% for the cyclothymic patients. The average probability of suffering one depressive episode severe enough to require either pharmacologic intervention or hospitalization in a 2-year period was 51% for the bipolar II patients, 64% for the unipolar patients, and 69% for the cyclothymic patients.