Stable sound decoding despite modulated sound representation in the auditory cortex.
Stable sound decoding despite modulated sound representation in the auditory cortex.
复制标题
尽管听觉皮层中的声音表示已调制，但声音解码仍然稳定。
DOI：
10.1101/2023.01.31.526457
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Zador,AnthonyM
中科院分区：
文献类型：
--
作者：
Funamizu,Akihiro;Marbach,Fred;Zador,AnthonyM
听觉皮层中神经元的活动受到声音和非感官环境的驱动。为了研究非感觉环境的神经元相关性，我们训练头部固定的小鼠执行两个备选选择听觉任务，其中奖励或刺激期望（先验）被操纵在块中。使用双光子钙成像记录听觉皮层中的单个神经元的群体，我们发现刺激和奖励期望都调制这些神经元的活动。在这种群体活动上训练的线性解码器可以解码刺激，以及或优于动物的表现预测。有趣的是，即使面对可变的感官表征，最佳解码器也是稳定的。无论是上下文还是老鼠的选择都不能从记录的神经活动中可靠地解码出来。我们的研究结果表明，尽管调制的听觉皮层活动的任务先验，听觉皮层并不代表足够的信息，这些先验最佳地利用它们。因此，快速变化的感觉信息与在这项任务中做出决策所需的更缓慢变化的任务信息的组合可能在听觉皮层以外的大脑区域中表现出来。
The activity of neurons in the auditory cortex is driven by both sounds and non-sensory context. To investigate the neuronal correlates of non-sensory context, we trained head-fixed mice to perform a two-alternative-choice auditory task in which either reward or stimulus expectation (prior) was manipulated in blocks. Using two-photon calcium imaging to record populations of single neurons in the auditory cortex, we found that both stimulus and reward expectation modulated the activity of these neurons. A linear decoder trained on this population activity could decode stimuli as well or better than predicted by the animal's performance. Interestingly, the optimal decoder was stable even in the face of variable sensory representations. Neither the context nor the mouse's choice could be reliably decoded from the recorded neural activity. Our findings suggest that, in spite of modulation of auditory cortical activity by task priors, the auditory cortex does not represent sufficient information about these priors to exploit them optimally. Thus, the combination of rapidly changing sensory information with more slowly varying task information required for decisions in this task might be represented in brain regions other than the auditory cortex.