lncRNA/MicroRNA interactions in the vasculature.
lncRNA/MicroRNA interactions in the vasculature.
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DOI：
10.1002/cpt.355
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发表时间：
2016-05
影响因子：
6.7
通讯作者：
Baker AH
中科院分区：
文献类型：
--
作者：
Ballantyne MD;McDonald RA;Baker AH
MicroRNA (miRNA) 因其在血管生成、细胞凋亡、增殖和迁移等多种血管过程中的作用而受到广泛关注。尽管人们对 miRNA 的表达和功能有了深入的了解，但对长链非编码 RNA (lncRNA) 分子机制的了解仍然有限。 miRNA 对 lncRNA 功能的影响以及相反的影响现在开始显现。 lncRNA可能通过充当内源性海绵来调节基因表达来调节miRNA功能，并且miRNA已被证明可以结合并调节lncRNA稳定性。详细了解 lncRNA-miRNA 介导的相互作用在血管病理生理学中的分子和细胞效应可能为新的诊断标记物和治疗方法铺平道路，但首先需要更详细地了解此类调节网络的影响。
MicroRNA (miRNA) have gained widespread attention for their role in diverse vascular processes including angiogenesis, apoptosis, proliferation, and migration. Despite great understanding of miRNA expression and function, knowledge of long noncoding RNA (lncRNA) molecular mechanisms still remains limited. The influence of miRNA on lncRNA function, and the converse, is now beginning to emerge. lncRNA may regulate miRNA function by acting as endogenous sponges to regulate gene expression and miRNA have been shown to bind and regulate lncRNA stability. A detailed understanding of the molecular and cellular effects of lncRNA‐miRNA‐mediated interactions in vascular pathophysiology could pave the way for new diagnostic markers and therapeutic approaches, but first there is a requirement for a more detailed understanding of the impact of such regulatory networks.