Sulfated zwitterionic poly(sulfobetaine methacrylate) hydrogels promote complete skin regeneration
Sulfated zwitterionic poly(sulfobetaine methacrylate) hydrogels promote complete skin regeneration
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硫酸化两性离子聚（磺基甜菜碱甲基丙烯酸酯）水凝胶促进皮肤完全再生
DOI：
10.1016/j.actbio.2018.02.034
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发表时间：
2018-04-15
影响因子：
9.7
通讯作者：
Xiao, Jian
中科院分区：
文献类型：
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作者：
Wu, Jiang;Xiao, Zecong;Xiao, Jian
皮肤伤口愈合仍然是一个长期存在的挑战性问题，并受到异物反应的阻碍，包括严重的炎症反应、新生血管形成不良、上皮化不完全和 ECM 重塑缺陷。开发生物相容性聚合物与特定药物或生长因子相结合，被认为是治疗皮肤伤口的一种有前途的策略。人们在开发基于聚乙二醇 PEG 的伤口愈合聚合物方面进行了大量的研究工作，但对两性离子材料的研究较少，其中一些材料已证明其具有超低的体外结垢特性和体内的抗炎特性。在这里，我们合成了超低污染两性离子硫酸化聚（磺基甜菜碱甲基丙烯酸酯）（polySBMA）水凝胶，并将其应用于小鼠全层皮肤伤口。通过体内实验对伤口愈合过程中SBMA水凝胶对伤口闭合、上皮再形成率、ECM重塑、血管生成和巨噬细胞反应的愈合效果进行了组织学评估。集体结果表明，SBMA 水凝胶通过增强血管生成、减少炎症反应和调节巨噬细胞极化，促进小鼠全层切除急性伤口再生。一致地，与纯 PEG 水凝胶相比，将 SBMA 掺入 PEG 水凝胶中也提高了总体伤口愈合效率。这项工作证明了两性离子 SBMA 水凝胶作为治疗全层切除皮肤伤口的有前景的伤口敷料。 (C) 2018 Acta Materialia Inc. 由 Elsevier Ltd 出版。保留所有权利。
Skin wound healing is a still long-history challenging problem and impeded by the foreign-body reaction including severe inflammation response, poor neovascularization, incomplete re-epithelialization and defective ECM remodeling. Development of biocompatible polymers, in combination with specific drugs or growth factors, has been considered as a promising strategy to treat skin wounds. Significant research efforts have been made to develop poly(ethylene glycol) PEG-based polymers for wound healing, however less efforts has been paid to zwitterionic materials, some of which have demonstrated their super low-fouling property in vitro and anti-inflammatory property in vivo. Here, we synthesized ultra-low-fouling zwitterionic sulfated poly(sulfobetaine methacrylate) (polySBMA) hydrogels and applied them to full-thickness cutaneous wounds in mice. The healing effects of SBMA hydrogels on the wound closure, re-epithelialization ratio, ECM remodeling, angiogenesis, and macrophage responses during wound healing processes were histologically evaluated by in vivo experiments. Collective results indicate that SBMA hydrogels promote full-thickness excisional acute wound regeneration in mice by enhancing angiogenesis, decreasing inflammation response, and modulating macrophage polarization. Consistently, the incorporation of SBMA into PEG hydrogels also improved the overall wound healing efficiency as compared to pure PEG hydrogels. This work demonstrates zwitterionic SBMA hydrogels as promising wound dressings for treating full-thickness excisional skin wounds. (C) 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.