Analysis of biostructural changes, dynamics, and interactions - Small-angle X-ray scattering to the rescue
Analysis of biostructural changes, dynamics, and interactions - Small-angle X-ray scattering to the rescue
复制标题
DOI：
10.1016/j.abb.2016.02.029
复制
发表时间：
2016-07-15
影响因子：
3.9
通讯作者：
Vestergaard, Bente
中科院分区：
文献类型：
--
作者：
Vestergaard, Bente
生物大分子溶液小角X射线散射（BioSAXS）在生物结构研究中发挥着越来越重要的作用。SAXS数据有助于分析复杂的蛋白质混合物、动态平衡、内在无序和不断演变的结构过程，无论是在独立应用中，还是在混合生物结构分析中发挥重要作用。这主要是由于硬件和软件的重大进步，特别是在大型设施中。在这里，最近的事态发展和BioSAXS的未来潜力进行审查，举例说明了许多优雅的应用程序，具有挑战性的系统的例子。(C)2016作者爱思唯尔公司出版
Solution small angle X-ray scattering from biological macromolecules (BioSAXS) plays an increasingly important role in biostructural research. The analysis of complex protein mixtures, dynamic equilibriums, intrinsic disorder and evolving structural processes is facilitated by SAXS data, either in standalone applications, or with SAXS taking a prominent role in hybrid biostructural analysis. This is not the least due to the significant advances in both hardware and software that have taken place in particular at the large-scale facilities. Here, recent developments and the future potential of BioSAXS are reviewed, exemplified by numerous examples of elegant applications to challenging systems. (C) 2016 The Author. Published by Elsevier Inc.