Biology of the molybdenum cofactor
Biology of the molybdenum cofactor
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DOI：
10.1093/jxb/erm024
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发表时间：
2007-01-01
影响因子：
6.9
通讯作者：
Mendel, Ralf R.
中科院分区：
文献类型：
--
作者：
Mendel, Ralf R.
过渡元素钼（Mo）是植物必需的微量营养素，在酶催化过程中需要作为催化活性金属。四种植物酶依赖于钼：硝酸还原酶，亚硫酸氧化酶，黄嘌呤脱氢酶和醛氧化酶。然而，为了获得生物活性并实现其在酶中的功能，钼必须与蝶呤化合物络合，从而形成钼辅因子。在这篇文章中，钼从其摄取到细胞的路径，通过形成钼辅因子和其存储，钼辅因子的最终修饰和其插入脱辅基金属酶将进行审查。
The transition element molybdenum (Mo) is an essential micronutrient for plants where it is needed as a catalytically active metal during enzyme catalysis. Four plant enzymes depend on molybdenum: nitrate reductase, sulphite oxidase, xanthine dehydrogenase, and aldehyde oxidase. However, in order to gain biological activity and fulfil its function in enzymes, molybdenum has to be complexed by a pterin compound thus forming the molybdenum cofactor. In this article, the path of molybdenum from its uptake into the cell, via formation of the molybdenum cofactor and its storage, to the final modification of the molybdenum cofactor and its insertion into apo-metalloenzymes will be reviewed.