p63 is the molecular switch for initiation of an epithelial stratification program
p63 is the molecular switch for initiation of an epithelial stratification program
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DOI：
10.1101/gad.1165104
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发表时间：
2004-01-15
影响因子：
10.5
通讯作者：
Roop, DR
中科院分区：
文献类型：
--
作者：
Koster, MI;Kim, S;Roop, DR
复层上皮如表皮的发育需要p63表达。p63基因编码含有（TA）或缺乏（DeltaN）反式激活结构域的同种型。我们证明，TAp63亚型是第一个在胚胎发生过程中表达，并需要启动上皮分层。此外，TAp63同种型抑制终末分化，表明TAp63同种型必须被DeltaNp63同种型平衡，以允许细胞响应胚胎表皮成熟所需的信号。我们的数据表明，p63起着双重作用：在发育过程中启动上皮分层和维持基底角质细胞在成熟表皮中的增殖潜力。
Development of stratified epithelia, such as the epidermis, requires p63 expression. The p63 gene encodes isoforms that contain (TA) or lack (DeltaN) a transactivation domain. We demonstrate that TAp63 isoforms are the first to be expressed during embryogenesis and are required for initiation of epithelial stratification. In addition, TAp63 isoforms inhibit terminal differentiation, suggesting that TAp63 isoforms must be counterbalanced by DeltaNp63 isoforms to allow cells to respond to signals required for maturation of embryonic epidermis. Our data demonstrate that p63 plays a dual role: initiating epithelial stratification during development and maintaining proliferative potential of basal keratino-cytes in mature epidermis.