The human DDX and DHX gene families of putative RNA helicases
The human DDX and DHX gene families of putative RNA helicases
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DOI：
10.1016/s0888-7543(03)00049-1
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发表时间：
2003-06-01
期刊：
影响因子：
4.4
通讯作者：
Wain, H
中科院分区：
文献类型：
--
作者：
Abdelhaleem, M;Maltais, L;Wain, H
核酸解旋酶的特征在于存在含有八个基序的解旋酶结构域。解旋酶结构域的序列用于将解旋酶分类为家族。为了鉴定人RNA解旋酶DEAD和DEAH家族的成员，我们使用解旋酶结构域序列搜索非冗余肽序列数据库。我们报告的36和14个成员的DEAD和DEAH家族的推定RNA解旋酶，包括几个新的基因的鉴定。基因符号DDX先前已用于DEAD盒和DEAR盒家族。我们现在采用DDX和DHX符号分别表示DEAD和DEAH盒族。人类DDX和DHX家族成员在分化和癌变中发挥作用。(C)2003 Elsevier Science（美国）。All rights reserved.
Nucleic acid helicases are characterized by the presence of the helicase domain containing eight motifs. The sequence of the helicase domain is used to classify helicases into families. To identify members of the DEAD and DEAH families of human RNA helicases, we used the helicase domain sequences to search the nonredundant peptide sequence database. We report the identification of 36 and 14 members of the DEAD and DEAH families of putative RNA helicases, including several novel genes. The gene symbol DDX had been used previously for both DEAD- and DEAR-box families. We have now adopted DDX and DHX symbols to denote DEAD- and DEAH-box families, respectively. Members of human DDX and DHX families of putative RNA helicases play roles in differentiation and carcinogenesis. (C) 2003 Elsevier Science (USA). All rights reserved.