Intraduodenal and intrajejunal administration of the herbal medicine, dai-kenchu-tou, stimulates small intestinal motility via cholinergic receptors in conscious dogs
Intraduodenal and intrajejunal administration of the herbal medicine, dai-kenchu-tou, stimulates small intestinal motility via cholinergic receptors in conscious dogs
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DOI：
10.1023/a:1010690624187
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发表时间：
2001-06-01
影响因子：
3.1
通讯作者：
Sasaki, I
中科院分区：
文献类型：
--
作者：
Jin, XL;Shibata, C;Sasaki, I
本研究的目的是研究十二指肠内和空肠内大健中汤对上消化道运动的影响和作用机制，大健中汤是一种临床上对无并发症的术后粘连性肠梗阻有效的草药。五只杂种狗在胃窦、十二指肠、近端和远端空肠上配备了四个应变式力传感器，以测量收缩活动。将Dai-kenchu-to（0.5、1.5和3.0 g）注入十二指肠或近端空肠腔。研究了阿托品、六甲双铵、酚妥拉明、心得安和昂丹司琼对十二指肠内和空肠内代根曲诱发的收缩的影响。用特异性放射免疫法测定血浆胃动素。十二指肠内和空肠内的大Kenchu诱导阶段性收缩，分别在十二指肠和近端空肠，这些收缩向远端迁移。在所有部位，阿托品和六烃季铵均能抑制十二指肠内和空肠内注射大剑中托引起的相性收缩。血浆胃动素不受大剑中汤的影响。十二指肠内和空肠内注射大健中-to通过胆碱能受体刺激给药部位及其远端的上消化道运动。
The aim of the present study was to study the effect and mechanism of action of intraduodenal and intrajejunal dai-kenchu-to, an herbal medicine clinically effective for uncomplicated postoperative adhesive intestinal obstruction, on upper gastrointestinal motility. Five mongrel dogs were equipped with four strain-gauge force transducers on the antrum, duodenum, and proximal and distal jejunum to measure contractile activity. Dai-kenchu-to (0.5, 1.5, and 3.0 g) was administered into the duodenal or proximal jejunal lumen. The effect of atropine, hexamethonium, phentolamine, propranolol, and ondansetron on intraduodenal and intrajejunal dai-kenchu-to-induced contractions was studied. Plasma motilin was measured by specific radioimmunoassay. Intraduodenal and intrajejunal dai-kenchu-to induced phasic contractions in the duodenum and proximal jejunum, respectively, and those contractions migrated distally. Phasic contractions induced by intraduodenal and intrajejunal daikenchu-to were inhibited by atropine and hexamethonium at all sites. Plasma motilin was not affected by dai-kenchu-to. Intraduodenal and intrajejunal dai-kenchu-to stimulates upper gastrointestinal motility at and distal to the administration sites through cholinergic receptors.