Sero-prevalence and mother-to-infant transmission of hepatitis E virus among pregnant women in the United Arab Emirates
Sero-prevalence and mother-to-infant transmission of hepatitis E virus among pregnant women in the United Arab Emirates
复制标题
DOI：
10.1016/s0301-2115(01)00448-1
复制
发表时间：
2001-12-10
期刊：
影响因子：
--
通讯作者：
Thomas, L
中科院分区：
文献类型：
--
作者：
Kumar, RM;Uduman, S;Thomas, L
目的：(1)研究阿拉伯联合酋长国(UAE)孕妇中HEV感染的流行情况。(2)母婴传播率。方法：对居住在阿联酋的469名孕妇采用酶联免疫吸附试验检测抗-HEV，聚合酶链式反应检测HEV-RNA。新生儿脐带血和婴儿血同样进行了抗-HEV和HEV-RNA检测。在这469名妇女中，33%分别是阿联酋国民(A组)和埃及人(B组)，34%来自印度次大陆(C组)。结果：在469名母亲中，93名(20%)抗-HEV阳性，其中28名(30%)HEV-RNA阳性且有持续感染的症状。抗-HEV感染率在B、C两组间差异有统计学意义(A组：B组，P
Objectives: (1) To study the prevalence of HEV infection in a cohort of pregnant women in the United Arab Emirates (UAE). (2) The rate of mother-to-infant transmission. Method: Sera of 469 pregnant women residing in the UAE was tested for anti-HEV with ELISA and for HEV-RNA by polymerase chain reaction (PCR). Neonatal cord-blood and infant blood was similarly tested for anti-HEV and HEV-RNA. Out of these 469 women, 33% were UAE nationals (Group A) and Egyptians (Group B), respectively, and 34% were from the Indian sub-continent (Group C). Results: Out of 469 mothers 93 (20%) were anti-HEV positive and 28 (30%) of these 93 were HEV-RNA positive and symptomatic with on-going infection. The prevalence of anti-HEV was significantly increased amongst Groups B and C (Group A:B, P