Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature
Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature
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DOI：
10.1016/j.ijantimicag.2012.02.007
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发表时间：
2012-06-01
影响因子：
10.8
通讯作者：
Akamatsu, Yuzuru
中科院分区：
文献类型：
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作者：
Hiramatsu, Keiichi;Igarashi, Masayuki;Akamatsu, Yuzuru
通过筛选土壤细菌的培养物，我们重新发现了一种古老的抗生素（尼博霉素）作为具有新特性的抗生素。尼博霉素对gyrA基因突变的耐喹诺酮金黄色葡萄球菌菌株有活性，但对喹诺酮类抗生素有效的gyrA基因完整的菌株无活性。从耐喹诺酮、敏感的万古霉素中间体S.金黄色葡萄球菌（VISA）菌株Mu50。突变体，发生率极低（
By screening cultures of soil bacteria, we re-discovered an old antibiotic (nybomycin) as an antibiotic with a novel feature. Nybomycin is active against quinolone-resistant Staphylococcus aureus strains with mutated gyrA genes but not against those with intact gyrA genes against which quinolone antibiotics are effective. Nybomycin-resistant mutant strains were generated from a quinolone-resistant, nybomycin-susceptible, vancomycin-intermediate S. aureus (VISA) strain Mu50. The mutants, occurring at an extremely low rate (