HEAT TRANSFER MODEL AND QUANTITATIVE ANALYSIS OF DEEP TISSUE INJURY.
HEAT TRANSFER MODEL AND QUANTITATIVE ANALYSIS OF DEEP TISSUE INJURY.
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DOI：
10.1115/imece2012-88405
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发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Herman C
中科院分区：
文献类型：
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作者：
Chanmugam A;Bhargava A;Herman C
深层组织损伤（DTI）是由于持续的组织负荷或缺血性损伤而可能在深层组织层发生的严重病变。这些病变可能在皮肤表面不可见，直到损伤达到晚期，使其早期检测成为一项具有挑战性的任务。早期诊断导致早期治疗减轻病变的进展，仍然是管理的重点之一。本研究的目的是检查受损组织的皮肤表面温度分布，并制定检测早期DTI的标准。利用有限元软件COMSOL Multiphysics建立了多层皮肤组织的定量传热模型。计算深层组织炎症和缺血时皮肤表面的热反应，并与健康组织的热反应进行比较。在DTI存在的情况下，在深部组织炎症的初始阶段，皮肤表面温度升高约0.5°C，随后皮肤表面温度下降约0.2°C，对应于持续的深部组织缺血。这些温差大到足以用热成像技术检测出来。因此，这项研究也增强了对先前检测到的与DTI相关的热成像定量变化的理解。
Deep tissue injuries (DTI) are serious lesions which may develop in deep tissue layers as a result of sustained tissue loading or ischemic injury. These lesions may not become visible on the skin surface until the injury reaches an advanced stage making their early detection a challenging task. Early diagnosis leading to early treatment mitigates the progression of lesion and remains one of the priorities in management. The aim of this study is to examine skin surface temperature distributions of damaged tissue and develop criteria for the detection of incipient DTI. A multilayer quantitative heat transfer model of the skin tissue was developed using finite element based software COMSOL Multiphysics. Thermal response of the skin surface was computed during deep tissue inflammation and deep tissue ischemia and then compared with that of healthy tissue. In the presence of a DTI, an increase of about 0.5°C in skin surface temperatures was noticed during initial phase of deep tissue inflammation, which was followed by a surface temperature decrease of about 0.2°C corresponding to persistent deep tissue ischemia. These temperature differences are large enough to be detected by thermographic imaging. This study, therefore, also enhances the understanding of the previously detected thermographic quantitative changes associated with DTI.