Regulation of autophagy by some natural products as a potential therapeutic strategy for cardiovascular disorders
Regulation of autophagy by some natural products as a potential therapeutic strategy for cardiovascular disorders
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DOI：
10.1016/j.ejphar.2017.02.038
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发表时间：
2017-05-05
影响因子：
5
通讯作者：
Karimi, Gholamreza
中科院分区：
文献类型：
--
作者：
Hashemzaei, Mahmoud;Heravi, Reza Entezari;Karimi, Gholamreza
自噬是一种溶酶体降解过程，通过该过程，长寿命和错误折叠的蛋白质和细胞器被溶酶体隔离、降解和回收。自噬是心肌细胞稳态的重要组成部分，并增加细胞在细胞应激和饥饿后的存活。最近的研究表明，自噬在心血管系统中的失调导致心脏肥大和衰竭。以这种方式，自噬似乎是心血管疾病新治疗中的一个有吸引力的靶点。虽然自噬的有限激活通常被认为是心脏保护性的，但过度的自噬导致细胞死亡和心脏萎缩。存在于我们饮食中的天然产物如白藜芦醇、小檗碱和姜黄素可以通过经典（Beclin-l依赖性）和非经典（Beclin-l独立性）途径触发自噬。这些化合物的自噬修饰能力应被考虑用于设计新的治疗剂。本文综述了自噬在这些化合物的心脏保护作用中的作用。
Autophagy is a lysosomal degradation process through which long-lived and misfolded proteins and organelles are sequestered, degraded by lysosomes, and recycled. Autophagy is an essential part of cardiomyocyte homeostasis and increases the survival of cells following cellular stress and starvation. Recent studies made clear that dysregulation of autophagy in the cardiovascular system leads to heart hypertrophy and failure. In this manner, autophagy seems to be an attractive target in the new treatment of cardiovascular diseases. Although limited activation of autophagy is generally considered to be cardioprotective, excessive autophagy leads to cell death and cardiac atrophy. Natural products such as resveratrol, berberine, and curcumin that are present in our diet, can trigger autophagy via canonical (Beclin-l-dependent) and non-canonical (Beclin-l-independent) pathways. The autophagy-modifying capacity of these compounds should be taken into consideration for designing novel therapeutic agents. This review focuses on the role of autophagy in the cardioprotective effects of these compounds.