Mycobacterium tuberculosis Mutations Associated with Reduced Susceptibility to Linezolid
Mycobacterium tuberculosis Mutations Associated with Reduced Susceptibility to Linezolid
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结核分枝杆菌突变与利奈唑胺敏感性降低相关
DOI：
10.1128/aac.02941-15
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发表时间：
2016-04-01
影响因子：
4.9
通讯作者：
Zhang, Ying
中科院分区：
文献类型：
--
作者：
Zhang, Shuo;Chen, Jiazhen;Zhang, Ying
摘要利奈唑胺(LZD)在耐多药结核病(MDR-TB)的治疗中发挥着越来越重要的作用，但其耐药机制尚不清楚。我们分离了32株对LZD敏感性降低的结核分枝杆菌突变株，这是由RRL和RPLC突变几乎相等的比例造成的，分别导致较低和较高的MIC。我们的发现为快速检测LZD耐药性以改进耐多药结核病的治疗提供了有用的信息。
ABSTRACT Linezolid (LZD) has become increasingly important for the treatment of multidrug-resistant tuberculosis (MDR-TB), but its mechanisms of resistance are not well characterized. We isolated 32 mutants of Mycobacterium tuberculosis with reduced susceptibility to LZD, which was accounted for by rrl and rplC mutations in almost equal proportions, causing lower and higher MICs, respectively. Our findings provide useful information for the rapid detection of LZD resistance for improved treatment of MDR-TB.