Hydrogen Sulfide Is Produced in Response to Neuronal Excitation
Hydrogen Sulfide Is Produced in Response to Neuronal Excitation
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DOI：
10.1523/jneurosci.22-09-03386.2002
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发表时间：
2002-05
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影响因子：
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通讯作者：
K. Eto;Miki Ogasawara;K. Umemura;Y. Nagai;H. Kimura
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作者：
K. Eto;Miki Ogasawara;K. Umemura;Y. Nagai;H. Kimura
虽然硫化氢（H2S）通常被认为是一种有毒气体，但它是在大脑中内源性产生的。生理浓度的H2S选择性增强NMDA受体介导的反应，并改变海马长时程增强（LTP）的诱导。在这里，我们使用胱硫醚β-合成酶（CBS）基因敲除小鼠，以清楚地表明，CBS产生内源性H2S在大脑中，H2S的生产大大增强兴奋性神经递质谷氨酸，以及通过电刺激。这种增加的CBS活性受涉及Ca 2 +/钙调蛋白的途径调节。此外，CBS基因敲除小鼠的LTP也发生了改变。这些观察结果表明，H2S是由CBS在响应神经元的兴奋，它可以调节突触活动的某些方面。
Although hydrogen sulfide (H2S) is generally thought of in terms of a poisonous gas, it is endogenously produced in the brain. Physiological concentrations of H2S selectively enhance NMDA receptor-mediated responses and alter the induction of hippocampal long-term potentiation (LTP). Here we use cystathionine β-synthase (CBS) knock-out mice to clearly show that CBS produces endogenous H2S in the brain and that H2S production is greatly enhanced by the excitatory neurotransmitterl-glutamate, as well as by electrical stimulation. This increased CBS activity is regulated by a pathway involving Ca2+/calmodulin. In addition, LTP is altered in CBS knock-out mice. These observations suggest that H2S is produced by CBS in response to neuronal excitation and that it may regulate some aspects of synaptic activity.