TB infection and BCG vaccination: are we protected from COVID-19?
TB infection and BCG vaccination: are we protected from COVID-19?
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DOI：
10.1016/j.puhe.2020.05.042
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发表时间：
2020-08-01
期刊：
影响因子：
5.2
通讯作者：
Mittal, S.
中科院分区：
文献类型：
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作者：
Madan, M.;Pahuja, S.;Mittal, S.
目的：2019年新型冠状病毒病（COVID-19）的发病率在世界不同地区存在差异。除了旅行模式之外，决定这种差异的其他因素可能包括宿主免疫反应。本研究的目的是评估结核病（TB）地方性和卡介苗（BCG）接种率对COVID-19的影响。研究设计：这是一项横断面研究。方法：我们回顾了174个国家关于结核病发病率、卡介苗接种率（根据世界卫生组织）和COVID-19发病率的现有数据。我们根据结核病年发病率和卡介苗覆盖率将这些国家分为四个队列。结果：结核病发病率高的国家的COVID-19水平低于结核病发病率低的国家。同样，BCG覆盖率高的国家COVID-19的发病率较低，这表明结核病流行地区存在一些保护机制。然而，生态差异和不同的检测策略在国家之间无法解释在此analysis.Conclusion：较高的结核病发病率和卡介苗覆盖率被发现与较低的COVID-19发病率相关。这一结果为进一步研究COVID-19的发病机制和免疫反应铺平了道路。(C)2020年皇家公共卫生学会。由爱思唯尔有限公司出版。保留所有权利。
Objectives: The incidence of emerging coronavirus disease 2019 (COVID-19) disease is variable across the different parts of the world. Apart from travel patterns, other factors determining this difference may include host immune response. The aim of this study was to assess the effect of tuberculosis (TB) endemicity and Bacille Calmette-Guerin (BCG) coverage on COVID-19.Study design: This was a cross-sectional study.Methods: We reviewed available data regarding TB incidence, BCG coverage (as per the World Health Organization), and COVID-19 incidence of 174 countries. We divided the countries into four cohorts depending on annual TB incidence and BCG coverage.Results: Countries with high TB incidence had lower COVID-19 than countries with low TB incidence. Similarly, countries with high BCG coverage had lower incidence of COVID-19, suggesting some protective mechanisms in TB-endemic areas. However, the ecological differences and different testing strategies between countries could not be accounted for in this analysis.Conclusion: Higher TB incidence and BCG coverage were found to be associated with lesser incidence of COVID-19. This outcome paves the way for further research into pathogenesis and immune response in COVID-19. (C) 2020 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.