HYPERPLASIA OF ELASTIC TISSUE IN HEPATIC SCHISTOSOMAL FIBROSIS
HYPERPLASIA OF ELASTIC TISSUE IN HEPATIC SCHISTOSOMAL FIBROSIS
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DOI：
10.1590/s0074-02761991000400014
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发表时间：
1991-10-01
影响因子：
2.8
通讯作者：
FREITAS, LAR
中科院分区：
文献类型：
--
作者：
ANDRADE, ZA;FREITAS, LAR
弹性组织增生，通过组织学，免疫细胞化学和超微结构的方法显示，出现了一个显着的变化，从61例肝门静脉周围和间隔纤维化患者的手术肝活检。 这种增生是不存在的实验鼠血吸虫病，包括小鼠与“管茎”fibrosis.Displaced结缔组织细胞在门静脉周围地区，如平滑肌细胞，更经常观察到在人类材料，可能是网站的过度弹性蛋白合成，并可以解释在人类和实验材料中观察到的差异。 弹性组织，有时代表其微纤维成分，也出现了更多的凝聚在领域的基质（胶原）降解，这表明该组织的参与在重塑的细胞外matrix.By其rectratile属性的弹性组织增生肝血吸虫病可能会导致血管狭窄，从而发挥作用的门静脉高压症的发病机制。
Elastic tissue hyperplasia, revealed by means of histological, immunocytochemical and ultra-structural methods, appeared as a prominent change in surgical liver biopsies taken from 61 patients with schistosomal periportal and septal fibrosis. Such hyperplasia was absent in experimental murine schistosomiasis, including mice with "pipe-stem" fibrosis.Displaced connective tissue cells in periportal areas, such as smooth muscle cells, more frequently observed in human material, could be the site of excessive elastin synthesis, and could explain the differences observed in human and experimental materials. Elastic tissue, sometimes represented by its microfibrillar components, also appeared to be more condensed in areas of matrix (collagen) degradation, suggesting a participation of this tissue in the remodelling of the extracellular matrix.By its rectratile properties elastic tissue hyperplasia in hepatic schistosomiasis can cause vascular narrowing and thus play a role in the pathogenesis of portal hypertension.