New type of representation for mapping chain-folding in protein molecules
New type of representation for mapping chain-folding in protein molecules
复制标题
绘制蛋白质分子链折叠图谱的新型表示法
作者：
R. Balasubramanian
小分子的构象细节可以很容易地在晶体学家使用的通常立体图中可视化，但是对于由数千个原子组成的蛋白质分子，这些细节不容易可视化。对于这样的大分子来说，为了描绘它们的三维结构，需要特殊类型的表示法，即二维图的形式。鉴于此，许多试图代表蛋白质分子的构象细节，已被驳回1 -7。我在这里提出了一个新的方法来映射蛋白质分子的骨架多肽链的折叠。这种表示法显示了蛋白质折叠的所有特征，没有因描绘构象细节而引起的简并性，并且在沿着链前进时，对于容易地识别所有二级结构而没有歧义是有用的。
CONFORMATIONAL details of small molecules can easily be visualised in the usual stereo diagrams used by crystallographers, but such details cannot be readily visualised for protein molecules made up of thousands of atoms. For such large molecules special types of representations become necessary for depicting their three-dimensional structure, in the form of two-dimensional diagrams. In view of this, many attempts to represent the conformational details in protein molecules, have been reported1–7. I present here a new method for mapping the folding of the backbone polypeptide chain of protein molecules. This representation brings out all the features of protein folding, with no degeneracy caused by depicting the conformational details, and is useful in readily recognising all the secondary structures, without ambiguity, as one progresses along the chain.