Steroid up-regulation of FKBP51 and its role in hormone signaling
Steroid up-regulation of FKBP51 and its role in hormone signaling
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DOI：
10.1016/j.coph.2011.04.006
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发表时间：
2011-08-01
影响因子：
4
通讯作者：
Palvimo, Jorma J.
中科院分区：
文献类型：
--
作者：
Jaaskelainen, Tiina;Makkonen, Harri;Palvimo, Jorma J.
FK506结合蛋白51 （FKBP51, FKBP5）是雄激素、糖皮质激素、矿物皮质激素和孕激素受体的共同伴侣。FKBP51可以作为对类固醇反应的重要决定因素，特别是应激和情绪障碍中的糖皮质激素和前列腺癌中的雄激素，提高了对该蛋白及其基因的医学和药理学兴趣。近年来的研究揭示了雄激素和糖皮质激素通过其核受体诱导FKBP51基因强烈上调的分子机制。FKBP51基因的几个多态性与情绪障碍和糖皮质激素敏感性的差异有关。这些多态性可能有助于FKBP51的类固醇上调，从而影响类固醇信号传导的调控回路。
FK506 binding protein 51 (FKBP51, FKBP5) functions as a co-chaperone for androgen, glucocorticoid, mineralocorticoid and progesterone receptors. The FKBP51 can act as an important determinant of the responses to steroids, especially to glucocorticoids in stress and mood disorders and androgens in prostate cancer, raising medical and pharmacological interests in the protein and its gene. Recent studies have revealed the molecular mechanisms by which the androgens and the glucocorticoids via their nuclear receptors elicit the robust up-regulation of the FKBP51 gene. Several polymorphisms in the FKBP51 gene have been associated with the mood disorders and differences in glucocorticoid sensitivity. The polymorphisms may contribute to the steroid up-regulation of the FKBP51 and thus influence the regulatory loops in steroid signaling.