ABNORMAL STIMULUS-PROCESSING IN POSTTRAUMATIC-STRESS-DISORDER
ABNORMAL STIMULUS-PROCESSING IN POSTTRAUMATIC-STRESS-DISORDER
复制标题
DOI：
10.1016/0006-3223(93)90088-u
复制
发表时间：
1993-09-01
影响因子：
10.6
通讯作者：
CLARK, CR
中科院分区：
文献类型：
--
作者：
MCFARLANE, AC;WEBER, DL;CLARK, CR
本研究调查了创伤后应激障碍（PTSD）患者信息处理的事件相关电位（EPP）指数。 ERP 是从 18 名 PTSD 患者和 20 名对照者身上获得的，当时他们执行目标辨别任务，需要从频繁和不频繁的干扰音调的背景序列中检测不频繁的目标音调。延迟的 N2 和减弱的 P3 无法区分目标和干扰音，表明患者在区分不同相关性的任务刺激时存在异常困难。有人提出，这种困难在行为上反映在患者对目标刺激的反应时间减慢上，并且可能是 PTSD 中发现的注意力分散和记忆障碍的基础。它还可能与中枢去甲肾上腺素功能障碍有关，中枢去甲肾上腺素功能已被证明对选择性注意力和创伤后应激障碍（PTSD）异常至关重要。
This study investigated event-related potential (EPP) indices of information processing in sufferers of posttraumatic stress disorder (PTSD). ERPs were obtained from 18 PTSD patients and 20 controls while they performed a target discrimination task requiring the detection of infrequent target tones from a background sequence of frequent and infrequent distractor tones. A delayed N2 and an attenuated P3 that failed to differentiate target from distractor tones indicated that patients had abnormal difficulty distinguishing task stimuli of differing relevance. It is proposed that this difficulty is reflected behaviorally in the slowed reaction time by patients to target stimuli and may underlie the disturbed concentration and memory impairments found in PTSD. It may also be related to dysfunction in central noradrenaline function, which has been shown to be both crucial in selective attention and abnormal in PTSD.