Expression of cell cycle regulating proteins in an unusual transformation of mantle cell lymphoma.
Expression of cell cycle regulating proteins in an unusual transformation of mantle cell lymphoma.
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套细胞淋巴瘤异常转化中细胞周期调节蛋白的表达。
DOI：
10.3109/10428199909145956
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发表时间：
1999
影响因子：
2.6
通讯作者：
A. Mikata
中科院分区：
文献类型：
--
作者：
J. Tamaru;H. Kawana;Y. Takahashi;N. Takahashi;K. Isobe;A. Hirai;Y. Saito;K. Harigaya;S. Itoyama;A. Mikata
我们在这里描述了两个病人与套细胞淋巴瘤（MCL）谁几年后，发展为弥漫性大细胞淋巴瘤（DLCL）（间变性中心细胞淋巴瘤）生长在一个弥漫性的床单没有经典的MCL组件。在初始和第二次活检标本中，在每种情况下，肿瘤细胞的细胞周期蛋白D1，sIgM，sIgD和CD 5阳性，但CD 10和CD 23阴性。在一项免疫球蛋白重链（IgH）基因重排研究中，使用聚合酶链反应（PCR）方法，从每个配对活检组织样本中获得的产物大小相同，并且在一种情况下具有与非突变VH基因相同的序列。免疫组化法检测p53、p27 Kip 1和cyclin E的表达。有趣的是，与其他典型MCL病例相比，病例1中有明显的p53蛋白过表达，而病例2中没有。p27 Kip 1在第二次活检中的表达较第一次活检明显降低。然而，在病例2中，p27 Kip 1在第一次和第二次活检中清楚地表达，与其他典型的MCL病例相反。因此，这2例病例不仅表明MCL的变异形式可能重新出现，而且MCL可能在复发时转化为DLCL。虽然肿瘤进展/转化的机制仍然知之甚少，但p53或p27 Kip 1的过表达可能与MCL变异形式发展中涉及的细胞机制有关。
We describe here two patients with mantle cell lymphoma (MCL) who after a few years, developed to the diffuse large cell lymphoma (DLCL) (anaplastic centrocytic lymphoma) growing in a diffuse sheets without the classical MCL component. In both the initial and second biopsy specimens, in each case, tumor cells were positive for cyclin D1, sIgM, sIgD, and CD5, but were negative for CD10 and CD23. In a study of immunoglobulin heavy chain (IgH) gene rearrangement, using the polymerase chain reaction (PCR) method, the products obtained from each paired biopsy tissue sample were the same size, and in one case had an identical sequence to the non-mutated VH gene. Immunohistochemistry was used to examine the expression of p53, p27Kip1 and cyclin E. Interestingly, there was clear overexpression of p53 protein in case 1 but not in case 2, compared with other typical MCL cases. The expression of p27Kip1 in the second biopsies of each case was decreased compared with those in the initial biopsies. In case 2, however, p27Kip1 was clearly expressed in the first and second biopsies, in contrast to other typical MCL cases. Thus these 2 cases demonstrate not only that the variant form of MCL may arise de novo, but also that MCL may transform to DLCL at the time of relapse. Although the mechanism of tumor progression/transformation is still poorly understood, the overexpression of p53 or p27Kip1 may be linked to a cellular mechanism involved in the development of the variant form of MCL.
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影响因子：
20.3
作者：
F. Coco;G. Gaidano;Diane;Louie;K. Offit;R. Chaganti;R. Dalla-Favera
通讯作者：
F. Coco;G. Gaidano;Diane;Louie;K. Offit;R. Chaganti;R. Dalla-Favera
影响因子：
20.3
作者：
T. Hirama;H. Koeffler
通讯作者：
T. Hirama;H. Koeffler
影响因子：
20.3
作者：
Greiner, TC;Moynihan, MJ;Weisenburger, DD
通讯作者：
Weisenburger, DD
BCL-1 (PRAD-1/cyclin D-1) 过表达可区分套细胞淋巴瘤的母细胞样变异型和 B 系淋巴母细胞淋巴瘤。
DOI：
--
发表时间：
1997
期刊：
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
影响因子：
--
作者：
Soslow,RA;Zukerberg,LR;Harris,NL;Warnke,RA
通讯作者：
Warnke,RA