Paranuclear dot-like immunostaining for CD99: presence in colonic adenomas and adenocarcinomas.
Paranuclear dot-like immunostaining for CD99: presence in colonic adenomas and adenocarcinomas.
复制标题
CD99 的核旁点状免疫染色：存在于结肠腺瘤和腺癌中。
DOI：
10.1097/pas.0b013e31822bb546
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Lee,NormanH
中科院分区：
文献类型：
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作者：
Makhoul,Rami;Schwartz,ArnoldM;Williams,Russell;Lee,NormanH
我们怀着极大的兴趣阅读了 Rege 等人在 2011 年 4 月号上发表的文章，描述了一小群胃肠道间质瘤 (GIST) 患者的组织学和临床特征，提出了一种称为“儿童型”的新疾病实体。特别是，他们报告了主要来自胃的 GIST 数据，平均大小为 5.4 厘米，主要影响中位年龄为 31.5 岁的女性。在显微镜下，它们显示出主要的混合上皮样细胞和梭形细胞形态，具有多结节结构。根据免疫组织化学结果，所有肿瘤均为 KIT 阳性，82% 的病例 DOG1 也呈阳性。分子分析显示它们是野生的
We read with considerable interest the article by Rege et al11 published in the April 2011 issue describing the histologic and clinical features of a small group of patients with gastrointestinal stromal tumors (GISTs) suggesting a new disease entity called “pediatric type.” In particular, they reported data on GISTs primarily arising from the stomach with a mean size of 5.4 cm and mainly affecting women with a median age of 31.5 years. Microscopically, they showed a predominant mixed epithelioid and spindle cell morphology with a multinodular architecture. On the basis of immunohistochemistry all tumors were positive for KIT, and 82% of cases were also positive for DOG1. Molecular analysis disclosed that they were wild