GENT2: an updated gene expression database for normal and tumor tissues
GENT2: an updated gene expression database for normal and tumor tissues
复制标题
DOI：
10.1186/s12920-019-0514-7
复制
发表时间：
2019-07-11
影响因子：
2.7
通讯作者：
Kim, Seon-Young
中科院分区：
文献类型：
--
作者：
Park, Seung-Jin;Yoon, Byoung-Ha;Kim, Seon-Young
正常与肿瘤组织基因表达数据库2 （gene Expression database of Normal and Tumor organizations，简称GENT2）是GENT的更新版本，它提供了一个用户友好的搜索平台，从公开的基因表达数据集中编译不同正常和肿瘤组织的基因表达模式。结果我们用最新的技术重构了gen2，如Apache Lucene索引，用于快速搜索和b谷歌Web Toolkit （GWT）框架，用于用户友好的Web界面。现在，GENT2包含超过68,000个样本，并具有几个新的有用功能。首先，gen2现在提供了72种不同组织的基因表达，而GENT只有57种。其次，随着肿瘤亚型的重要性日益提高，GENT2提供了基于肿瘤亚型研究差异表达及其预后意义的选项。第三，只要有机会，gen2就能提供感兴趣基因的预后信息。第四，gen2提供了生存信息的荟萃分析，为用户提供更可靠的感兴趣基因的预后价值。综上所述，随着这些显著的改进，GENT2将继续成为广泛研究人员的有用工具。GENT2可在http://gent2.appex.kr免费获得。
BackgroundGene Expression database of Normal and Tumor tissues 2 (GENT2) is an updated version of GENT, which has provided a user-friendly search platform for gene expression patterns across different normal and tumor tissues compiled from public gene expression data sets.ResultsWe refactored GENT2 with recent technologies such as Apache Lucene indexing for fast search and Google Web Toolkit (GWT) framework for a user-friendly web interface. Now, GENT2 contains more than 68,000 samples and has several new useful functions. First, GENT2 now provides gene expression across 72 different tissues compared to 57 in GENT. Second, with increasing importance of tumor subtypes, GENT2 provides an option to study the differential expression and its prognostic significance based on tumor subtypes. Third, whenever available, GENT2 provides prognostic information of a gene of interest. Fourth, GENT2 provides a meta-analysis of survival information to provide users more reliable prognostic value of a gene of interest.ConclusionsIn conclusion, with these significant improvements, GENT2 will continue to be a useful tool to a wide range of researchers. GENT2 is freely available at http://gent2.appex.kr.