Visuospatial learning impairment following lesion of the cholinergic projection to the hippocampus
Visuospatial learning impairment following lesion of the cholinergic projection to the hippocampus
复制标题
海马胆碱能投射损伤后的视觉空间学习障碍
DOI：
10.1016/0006-8993(88)90348-4
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发表时间：
1988
期刊：
影响因子：
2.9
通讯作者：
J. A. Johnson
中科院分区：
文献类型：
--
作者：
R. Ridley;N. Samson;H. Baker;J. A. Johnson
Ibotenic酸损毁恒河猴Broca斜角带(Vdb)垂直肢，可导致海马结构和内嗅皮层(vdb的胆碱能神经元投射到)的胆碱乙酰转移酶(ChAT)活性显著降低，乙酰胆碱酯酶(AChE)染色减少，但在新皮质或杏仁核中无明显变化。患有VDB损害的绒猴在获得(但不是保留)重复的试验视觉空间任务时受到损害。胆碱能激动剂匹罗卡品可缓解这种损害，表明(A)学习障碍是胆碱能系统受损的结果，(B)胆碱能投射在靶区发挥调节或使能功能，可被非脉冲依赖的药物作用所替代。与Meynert基底核(NBM)损毁的绒猴不同，VDB损伤的动物在学习重复试验对象辨别方面没有受到损害，尽管它们确实变得体温过低和中胚层，但在一般行为方面没有变化。这些结果与海马体(可能与内嗅皮层一起)主要与反应记忆有关，而不是对奖励的记忆有关，胆碱能系统的损伤会产生与终末区域消融相同的损伤。
Ibotenic acid lesions of the vertical limb of the diagonal band of Broca (VDB) in marmosets produced significant depletions in choline acetyltransferase (ChAT) activity and a decrease in acetylcholinesterase (AChE) staining in the hippocampal formation and entorhinal cortex (to which the cholinergic neurones of the VDB project) but not in the neocortex or amygdala. Marmosets with VDB lesions were impaired on acquisition (but not retention) of repeated trial visuospatial tasks. This impairment was amerliorated by pretreatment with the cholinergic agonist pilocarpine indicating (a) that the learning impairment was a consequence of damage to the cholinergic system and (b) that the cholinergic projections exert a modulatory or enabling function on the target areas which can be substituted by a non-impulse-dependent drug action. Unlike marmosets with lesions of the basal nucleus of Meynert (NBM), VDB-lesioned animals were not impaired on learning repeated trial object discrimination and showed no change in general behavior although they did become hypothermic and mesomorphic. These results are consistent with the suggestion that the hippocampus (perhaps in conjunction with the entorhinal cortex) is concerned primarily with memory for responses but not memory for reward and that lesions of the cholinergic system produce impairments equivalent to the effects of ablation of the terminal areas.
阿尔茨海默病中的乳头体。
影响因子：
3.5
作者：
Grossi,D;Lopez,OL;Martinez,AJ
通讯作者：
Martinez,AJ