The Developmental Gene Hypothesis for Punctuated Equilibrium: Combined Roles of Developmental Regulatory Genes and Transposable Elements.
The Developmental Gene Hypothesis for Punctuated Equilibrium: Combined Roles of Developmental Regulatory Genes and Transposable Elements.
复制标题
间断平衡的发育基因假说：发育调节基因和转座元件的联合作用。
DOI：
10.1002/bies.201900173
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Konkel,MiriamK
中科院分区：
文献类型：
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作者：
Casanova,EmilyL;Konkel,MiriamK
到目前为止，间断平衡（PE）的遗传学基础理论还很模糊。这里提出了发育基因假说，该假说指出：1）发育调节（DevReg）基因负责后生动物形态发生的协调，并且它们的极端保守和突变耐受性产生了贯穿大部分化石记录的平衡或停滞，以及2）调节元件的积累和这些相同基因内的重组-通常来自转座元件-驱动着后生动物形态分化和物种形成的间歇性爆发。这两部分假说有助于解释PE的特征，为曾经有争议的理论提供了理论遗传学基础。也可以在这里看到视频摘要www.example.com
Theories of the genetics underlying punctuated equilibrium (PE) have been vague to date. Here the developmental gene hypothesis is proposed, which states that: 1) developmental regulatory (DevReg) genes are responsible for the orchestration of metazoan morphogenesis and their extreme conservation and mutation intolerance generates the equilibrium or stasis present throughout much of the fossil record and 2) the accumulation of regulatory elements and recombination within these same genes—often derived from transposable elements—drives punctuated bursts of morphological divergence and speciation across metazoa. This two‐part hypothesis helps to explain the features that characterize PE, providing a theoretical genetic basis for the once‐controversial theory. Also see the video abstract here https://youtu.be/C-fu-ks5yDs