Vitamin D and Autoimmune Rheumatologic Disorders
Vitamin D and Autoimmune Rheumatologic Disorders
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DOI：
10.1016/j.autrev.2010.02.011
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发表时间：
2010-05-01
影响因子：
13.6
通讯作者：
Miller, Laurie C.
中科院分区：
文献类型：
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作者：
Pelajo, Christina F.;Lopez-Benitez, Jorge M.;Miller, Laurie C.
维生素D水平取决于许多变量，包括阳光暴露、年龄、种族、体重指数、药物和补充剂的使用。在没有UVB辐射的情况下，要保持足够的循环25(OH)D水平，需要比目前指南高得多的口服维生素D摄入量。除了传统的已知代谢活动外，维生素D还被证明可以调节免疫系统，其缺乏与几种自身免疫性疾病的发展有关，包括1型糖尿病和多发性硬化症。维生素D的实验应用揭示了在自身免疫性疾病的免疫发病机制中的新作用。系统性红斑狼疮、类风湿性关节炎、白塞病、多发性肌炎/硬皮炎和系统性硬皮病等疾病在一定程度上都与维生素D缺乏有关。如果自身免疫性疾病患者中维生素D缺乏率较高，则可能需要适当的补充。(C)2010爱思唯尔B.V.保留所有权利。
Vitamin D levels depend on many variables, including sun exposure, age, ethnicity, body mass index, use of medications and supplements. A much higher oral vitamin D intake than the current guidelines is necessary to maintain adequate circulating 25(OH)D levels in the absence of UVB radiation of the skin. In addition to the traditional known metabolic activities, vitamin D has been shown to modulate the immune system, and its deficiency has been linked to the development of several autoimmune disorders including type 1 diabetes and multiple sclerosis. Experimental use of vitamin D has revealed a novel role in the immunopathogenesis of autoimmune diseases. Disorders such as systemic lupus erythematosus, rheumatoid arthritis, Behcet's, polymyositis/clermatomyositis and systemic scleroderma have all been associated to some extent to vitamin D deficiency. If vitamin D deficiency occurs at a higher rate in patients with autoimmune disorders, then appropriate supplementation may be indicated. (C) 2010 Elsevier B.V. All rights reserved.