MAGNETIC-RESONANCE AND POSITRON EMISSION TOMOGRAPHY IMAGING OF THE CORPUS-CALLOSUM - SIZE, SHAPE AND METABOLIC-RATE IN UNIPOLAR DEPRESSION
MAGNETIC-RESONANCE AND POSITRON EMISSION TOMOGRAPHY IMAGING OF THE CORPUS-CALLOSUM - SIZE, SHAPE AND METABOLIC-RATE IN UNIPOLAR DEPRESSION
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DOI：
10.1016/0165-0327(93)90073-s
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发表时间：
1993-05-01
影响因子：
6.6
通讯作者：
LOTTENBERG, S
中科院分区：
文献类型：
--
作者：
WU, JC;BUCHSBAUM, MS;LOTTENBERG, S
应用磁共振成像（MRI）和正电子发射断层扫描（PET）对20例单相抑郁症患者和16例正常对照者胼胝体的大小和形态进行了研究。一种自动算法勾勒出胼胝体的轮廓，并将其分为四部分。胼胝体的前部和后部在抑郁症患者中比对照组大，这一发现与大多数精神分裂症患者胼胝体的早期MRI研究结果相似。女性患者与正常人之间的差异比男性更显著。胼胝体较薄或较小的患者PET葡萄糖代谢值较高。显著性别差异的存在使得未来控制体型和年龄的更大规模研究变得重要。
Magnetic resonance imaging (MRI) and positron emission tomography (PET) with fluorodeoxyglucose were used to study the size and shape of the corpus callosum in 20 patients with unipolar depressive disorder and 16 normal controls. An automated algorithm outlined the corpus callosum and divided it into quarters. The anterior and posterior quarters of the corpus callosum were larger in depressed patients than in controls, findings similar to most earlier MRI studies of the corpus callosum in schizophrenics. The patient-normal difference was more marked in females than in males. PET glucose metabolic values were higher in patients with thinner or smaller callosums. The presence of marked sex differences makes future larger studies controlling body size and age important.