New technologies for glaucoma imaging.
New technologies for glaucoma imaging.
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青光眼成像新技术。
DOI：
10.1155/2011/608975
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发表时间：
2011
影响因子：
1.9
通讯作者：
Weinreb,RobertN
中科院分区：
文献类型：
--
作者：
Leung,ChristopherKS;Medeiros,FelipeA;Garway-Heath,David;Greenfield,DavidS;Weinreb,RobertN
在过去的十年中，成像技术的发展重塑了我们诊断和管理青光眼患者的前景。采用技术进步并将新信息转化为临床实践，给临床医生和研究科学家带来了新的挑战。本期特刊收录了五篇文章，介绍了眼部成像和电生理技术的最新进展，并展示了这些进展如何增强我们对青光眼的理解。自2005年推出以来，光谱域光学相干断层扫描（SD-OCT）在视网膜神经纤维层（RNFL）和视盘成像方面受到了相当大的关注。随着轴向分辨率的提高，可以辨别各个视网膜层，现在可以用SD-OCT可靠地测量新参数，如神经节细胞复合体（GCC）和光感受器层厚度。ST Takagi等人证明，黄斑GCC厚度可以作为青光眼早期检测的生物标志物。由于黄斑中视网膜神经节细胞的高密度，可以想象测量黄斑GCC厚度对于青光眼评估将是有价值的。相比之下，外层视网膜预计不会受到影响。出乎意料的是，N。Fan等人的研究表明，轻度青光眼的外核层比正常眼厚。这一发现表明，昏迷性损害可能涉及光感受器的结构变化。
The evolution of imaging technologies over the past decade has reshaped our landscape in diagnosing and managing patients with glaucoma. Adopting technological advances and translating new information into clinical practice pose new challenges to both clinicians and research scientists. This special issue includes five papers covering some of the recent advances in ocular imaging and electrophysiology technologies and demonstrates how such advancement augments our understanding of glaucoma.Since its introduction in 2005, the spectral-domain optical coherence tomography (SD-OCT) has received considerable attention for retinal nerve fiber layer (RNFL) and optic disc imaging. With improved axial resolution to discern individual retinal layers, new parameters such as the ganglion cell complex (GCC) and the photoreceptor layer thicknesses can now be measured reliably with SD-OCT. ST Takagi and et al. demonstrate that macular GCC thickness could serve as a biomarker for early detection of glaucoma. With a high density of retinal ganglion cells in the macula, it is conceivable that measuring macular GCC thickness would be valuable for glaucoma assessment. By contrast, the outer retina would be expected to be unaffected. Unexpectedly, N. Fan et al. show that the outer nuclear layer is thicker in mild glaucomatous eyes than in normal eyes. This finding suggests glaucomatous damage may involve structural change in the photoreceptors.