The acute and sub-chronic effects of levocetirizine, cetirizine, loratadine, promethazine and placebo on cognitive function, psychomotor performance, and weal and flare
The acute and sub-chronic effects of levocetirizine, cetirizine, loratadine, promethazine and placebo on cognitive function, psychomotor performance, and weal and flare
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DOI：
10.1185/0300799019117011
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发表时间：
2001-01-01
影响因子：
2.3
通讯作者：
Shamsi, Z
中科院分区：
文献类型：
--
作者：
Hindmarch, I;Johnson, S;Shamsi, Z
目的：采用一系列精神和认知测试以及疼痛和潮红反应的测量，比较急性和亚慢性剂量的左西布嗪（L-CTZ）、西替利嗪（CTZ）、氯雷他定（LOR）和异丙嗪（PRM）与安慰剂对中枢和外周H1抑制作用。PRM作为阳性内部对照被包括在研究中，以验证心理测量测试组合对各种治疗的CNS效应的敏感性。20名健康志愿者（18-50岁）在一项五向、双盲、交叉研究中接受L-CTZ 5 mg、CTZ 10 mg、LOR 10 mg、PRM 30 mg和安慰剂，每日一次，持续4天。对于每种治疗条件，在基线和第1天和第4天给药后1、2、3、4、6、8、10和12小时，使用心理测试系统和对100 mg/ml组胺溶液的针刺肿胀和闪光反应来评估受试者。心理测量学包括临界闪烁融合（CFF）、选择反应时（CRT）、连续跟踪任务（CTT）和镇静主观评定量表（LARS）。在第2天和第3天，受试者在预先指定的时间服用药物，而不在单位。结果：验证（PRM）建立了测试电池的灵敏度：在第1天和第4天，CFF阈值显著降低（p
Aim: To compare the central and peripheral H1 inhibitory effects of acute and sub-chronic doses of levocebrizine (L-CTZ), cetirizine (CTZ), loratadine (LOR) and promethazine (PRM) versus placebo, using a battery of psychomotor and cognitive tests together with measures of the weal and flare reaction. PRM was included in the study as a positive internal control to validate the sensitivity of the psychometric test battery to the CNS effects of the various treatments.Methods: Twenty healthy volunteers (18-50 years) received L-CTZ 5 mg, CTZ 10 mg, LOR 10 mg, PRM 30 mg and placebo once daily for four days in a five-way, double-blind, crossover study, For each treatment condition, subjects were assessed using a psychometric test system and a pinprick weal and flare response to 100 mg/ml histamine solution at baseline and at 1, 2, 3, 4, 6, 8, 10 and 12 hours post-dose on days 1 and 4. The psychometrics comprised critical flicker fusion (CFF), choice reaction time (CRT), a continuous tracking task (CTT) and subjective rating scales for sedation (LARS). On days 2 and 3, subjects took their medication at pre-designated times while out of the unit.Results: The verum (PRM) established the sensitivity of the test battery: a significant overall reduction in CFF thresholds on both days 1 and 4 (p