Estimation of an accuracy index of a diagnostic biomarker when the reference biomarker is continuous and measured with error.
Estimation of an accuracy index of a diagnostic biomarker when the reference biomarker is continuous and measured with error.
复制标题
当参考生物标志物是连续的并且测量有误差时，诊断生物标志物的准确度指数的估计。
DOI：
10.1080/10543406.2016.1226330
复制
发表时间：
2016
影响因子：
1.1
通讯作者：
Liu,Aiyi
中科院分区：
文献类型：
--
作者：
Wu,Mixia;Zhang,Dianchen;Liu,Aiyi
为了诊断的目的，新的生物标志物继续被开发，并且它们的诊断性能通常与用于相同目的的现有参考生物标志物进行比较。当参考生物标志物是二分的时，相当多的研究集中在受试者工作特征曲线分析。在参考生物标志物在连续尺度上测量并且二分化实际上不吸引人的情况下，在文献中提出了一种指数来测量连续生物标志物的准确性，其基本上是流行的Kendall τ的线性函数。我们考虑的问题，估计这样的准确性指数时，连续的参考生物标志物测量误差。我们首先调查的影响，测量误差的准确性指标，然后提出的方法来纠正由于测量误差的偏差。仿真结果表明，所提出的估计在减少偏差的有效性。这些方法以从中心实验室和当地实验室获得的血红蛋白A1c测量值为例，以评估从计量血糖监测获得的平均数据与从1型糖尿病青年家庭行为干预研究获得的中心测量血红蛋白A1c的准确性。
New biomarkers continue to be developed for the purpose of diagnosis, and their diagnostic performances are typically compared with an existing reference biomarker used for the same purpose. Considerable amounts of research have focused on receiver operating characteristic curves analysis when the reference biomarker is dichotomous. In the situation where the reference biomarker is measured on a continuous scale and dichotomization is not practically appealing, an index was proposed in the literature to measure the accuracy of a continuous biomarker, which is essentially a linear function of the popular Kendall’s tau. We consider the issue of estimating such an accuracy index when the continuous reference biomarker is measured with errors. We first investigate the impact of measurement errors on the accuracy index, and then propose methods to correct for the bias due to measurement errors. Simulation results show the effectiveness of the proposed estimator in reducing biases. The methods are exemplified with hemoglobin A1c measurements obtained from both the central lab and a local lab to evaluate the accuracy of the mean data obtained from the metered blood glucose monitoring against the centrally measured hemoglobin A1c from a behavioral intervention study for families of youth with type 1 diabetes.