NEUROPEPTIDE AND MONOAMINE COMPONENTS OF THE PARABRACHIAL PONTINE COMPLEX
NEUROPEPTIDE AND MONOAMINE COMPONENTS OF THE PARABRACHIAL PONTINE COMPLEX
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DOI：
10.1016/0196-9781(87)90102-1
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发表时间：
1987-03-01
期刊：
影响因子：
3
通讯作者：
HOFFMAN, GE
中科院分区：
文献类型：
--
作者：
BLOCK, CH;HOFFMAN, GE
本文观察了免疫反应性神经降压素（NT）、八肽胆囊收缩素（CCK）、P物质（SP）、甲硫氨酸脑啡肽（ENK）、血管活性肠肽（VIP）、生长抑素（SS）、大鼠神经后叶素Ⅱ（RNP Ⅱ）、加压素（VP）、催产素（OXY）、酪氨酸羟化酶（TH）和5-羟色胺（5-HT）在大鼠臂旁核复合体（PB）的分布。所有这些物质都定位于PB，它们似乎是在复合物内化学结构上组织的。外侧亚部（PBL）由内侧-外侧和腹侧-背侧组成。具体NT，CCK，SP免疫反应纤维被认为是最密集的PBL的腹侧方面。含NT纤维的分布与含CCK纤维的分布相似，主要位于PBL的中央区。免疫反应阳性的SP纤维和细胞分布于PBL腹侧的外带和内带以及背核和背外侧核的周围。背侧PBL中生长抑素、ENK和VIP的密度最高。PBL和PBM中均可见含5-羟色胺和TH的细胞和纤维.这些结果，再加上PB的神经元连接和该地区的已知功能的观察，强调了这些神经肽和单胺在边缘脑干自主控制机制的潜在参与。
The present investigation examined the distributions of immunoreactive neurotensin (NT), cholecystokinin octapeptide (CCK), substance P (SP), methionine enkephalin (ENK), vasoactive intestinal polypeptide (VIP), somatostatin (SS), rat neurophysin II (RNP II), vasopressin (VP), oxytocin (OXY), tyrosine hydroxylase (TH), and serotonin in the parabrachial nuclear complex (PB) of the rat. All of these substances were localized to the PB and they appeared to be chemoarchitecturally organized within the complex. The lateral subdivision (PBL) was organized medial-lateral and ventral-dorsal. Specifically NT, CCK, and SP immunoreactive fibers were found to be the most dense in the ventral aspect of the PBL. The distribution of NT-containig fibers was similar to the pattern of CCK-containing fibers and these were localized primarily to the central zone of the PBL. Immunoreactive SP fibers and cells were found in the external and internal zones ventrally and surrounding the dorsal and dorsolateral nuclei in the PBL. Somatostatin, ENK and VIP were found to be the most dense in the dorsal PBL. Serotonin- and TH- containing cells and fibers were found in both the PBL and PBM. These results, coupled with the observations of neuronal connections of the PB and the known functions of this region, underscore the potential involvement for these neuropeptides and monoamines in limbic-brainstem mechanisms of autonomic control.